INT169747

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 16.64
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
astrocytes 3
vesicles 2
blood 1
spinal cord 1
muscles 1
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sicca syndrome 6 99.68 Very High Very High Very High
Central nervous system 151 99.44 Very High Very High Very High
headache 4 98.60 Very High Very High Very High
potassium channel 12 97.72 Very High Very High Very High
Analgesic 2 96.88 Very High Very High Very High
Spinal cord 141 96.04 Very High Very High Very High
Neuritis 110 94.76 High High
Inflammation 98 93.76 High High
Multiple sclerosis 169 92.72 High High
Sciatica 2 91.52 High High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 1173 100.00 Very High Very High Very High
Alzheimer's Dementia 24 100.00 Very High Very High Very High
Motor Neuron Diseases 76 99.84 Very High Very High Very High
Syndrome 54 99.68 Very High Very High Very High
Systemic Lupus Erythematosus 34 99.56 Very High Very High Very High
Glioblastoma 2 99.10 Very High Very High Very High
Disease 362 98.98 Very High Very High Very High
Atrophy 28 98.86 Very High Very High Very High
Headache 4 98.60 Very High Very High Very High
Encephalitis 2 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water channels.
Localization (colocalize) of AQP4
1) Confidence 0.75 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.19 Pain Relevance 0.17
The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water channels.
Localization (colocalize) of aquaporin 4
2) Confidence 0.75 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.19 Pain Relevance 0.17
As shown in Figure 1 we found co-localization of NMO Abs (red) with the AQP4 protein (green), whereas NMO Abs did not bind to EmGFP transfected cells.
Localization (localization) of AQP4 protein associated with neuromyelitis optica
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.35 Pain Relevance 0
Moreover, 27 patients with CIS, 29 patients with various OND (ischemic infarct, parkinson disease, epileptic seizure, radiculopathy, insomnia, sleep apnoea syndrome, CNS lymphoma, traumatic brain injury, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, vestibular neuritis, orthostatic syncope, psychogenic neurological symptoms, CNS vasculitis, hereditary neuropathy, analgesic-induced headache, neuroborreliosis, viral encephalitis, chronic tension-type headache, glioblastoma multiforme), 30 patients with SLE or SS and 47 HC were screened for AQP4-Ig.
Localization (screened) of AQP4 in brain associated with apnoea, neurological disease, syndrome, sicca syndrome, systemic lupus erythematosus, neuropathy, epilepsy, demyelination, inflammation, sleep disorders, parkinson's disease, analgesic, sciatica, myasthenia gravis, increased venous pressure under development, vestibular neuronitis, neuritis, lymphatic system cancer, glioblastoma, encephalitis, headache, central nervous system, syncope, demyelinating disease and brain injury
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 3.11 Pain Relevance 1.05
In addition, among their 21 NMO patients seropositive for AQP4 autoantibodies by cell-based IIFA, patients seropositive for NMO-IgG by tissue-based IIFA (15 patients) had a higher frequency of longitudinally extensive spinal cord lesions on MRI than patients seronegative for NMO-IgG by tissue-based IIFA (6 patients), 100% versus 50% (p = 0.015) [34]; this was not observed in our patients.
Localization (seropositive) of AQP4 in spinal cord associated with neuromyelitis optica and spinal cord
5) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 1.63 Pain Relevance 0.18
Higher magnification (Fig. 4 A) revealed apparent colocalization of EAAT2 and AQP4 in early endosomal vesicles to which we previously demonstrated AQP4 translocation after exposure to NMO serum (6).
Localization (colocalization) of AQP4 in vesicles associated with neuromyelitis optica
6) Confidence 0.73 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.13
The white color that resulted when the images were merged suggested partial colocalization of AQP4 and EAAT2 in early endosomes (Fig. 4 B).
Spec (partial) Localization (colocalization) of AQP4
7) Confidence 0.73 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.74 Pain Relevance 0.06
Colocalization of AQP4 and EAAT2 in CNS tissue
Localization (Colocalization) of AQP4 associated with central nervous system
8) Confidence 0.73 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.21 Pain Relevance 0.20
We evaluated the localization of AQP4 and the early endosome antigen-1 marker after exposing the cells to NMO serum for 10 min.
Localization (localization) of AQP4 associated with neuromyelitis optica
9) Confidence 0.73 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.10
Higher magnification (Fig. 4 A) revealed apparent colocalization of EAAT2 and AQP4 in early endosomal vesicles to which we previously demonstrated AQP4 translocation after exposure to NMO serum (6).
Localization (translocation) of AQP4 in vesicles associated with neuromyelitis optica
10) Confidence 0.73 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.13
A specific auto-antibody, NMO-IgG, was detected in the serum of NMO patients, and aquaporin-4 water channel protein was detected as its target antigen; aquaporin-4 water channel protein is localized at the end-feet of astrocytes.
Localization (localized) of aquaporin-4 in astrocytes associated with neuromyelitis optica
11) Confidence 0.73 Published 2010 Journal Brain Nerve Section Abstract Doc Link 20844302 Disease Relevance 1.57 Pain Relevance 0.31
As the cell-based IIFA requires technical expertise in the observation of GFP and AQP4 co-localization, tissue-based IIFA and FIPA may be more useful for clinical service, as it allows rapid large-scale screening for AQP4 autoantibodies, and cases that are serum negative by tissue-based IIFA and FIPA can be further studied for AQP4 autoantibodies by cell-based IIFA if clinical suspicion for NMOSD is high.


Localization (localization) of AQP4
12) Confidence 0.70 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0.32 Pain Relevance 0
The concept that pathogenic effects in NMOSD are predominantly brought about by blood derived AQP4-Ab is compatible with the unique localisation of the AQP4 antigen.
Localization (localisation) of AQP4 in blood
13) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.15 Pain Relevance 0
Correlation of CD19 counts and AQP4-Ab levels under treatment with rituximab
Localization (Correlation) of AQP4
14) Confidence 0.67 Published 2008 Journal Brain Section Body Doc Link PMC2577801 Disease Relevance 0.25 Pain Relevance 0.04
This study of Jimi and colleagues showed that changes in the levels of AQP4 mRNA in muscles with ALS and other neurogenic atrophies were essentially the same, although there was a greater decrease of AQP4 in ALS than in other neurogenic atrophies.
Localization (decrease) of AQP4 in muscles associated with atrophy and motor neuron diseases
15) Confidence 0.59 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.81 Pain Relevance 0
Water movement via the AQP4 water channel localized to astrocyte end-feet maintains osmotic balance and promotes effective potassium siphoning [71].
Localization (localized) of AQP4 in astrocyte
16) Confidence 0.59 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.67 Pain Relevance 0.13
Overall, these data point to a critical role for the NVU in AD [34, 105]: vascular amyloid deposition results in mislocalization of AQP4 expression and changes in expression levels of specific potassium channels, both of which are critical components of physiological systems designed to maintain the brain external milieu.


Localization (mislocalization) of AQP4 in external associated with alzheimer's dementia, potassium channel and disease
17) Confidence 0.55 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.03 Pain Relevance 0.08
A potential explanation for the loss of AQP4 and Kir4.1 channels is that they share a common anchoring protein that is affected by vascular amyloid deposition: the Dp71 dystrophin protein, localized on perivascular astrocytes [40].
Localization (localized) of AQP4 in astrocytes associated with alzheimer's dementia
18) Confidence 0.24 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.37 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox