INT169748

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 45
Disease Relevance 34.29
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
astrocytes 10
retina 9
lens 8
eyes 6
brain 4
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 516 100.00 Very High Very High Very High
Inflammation 152 100.00 Very High Very High Very High
imagery 189 99.28 Very High Very High Very High
glial activation 3 98.76 Very High Very High Very High
cerebral cortex 17 97.52 Very High Very High Very High
ischemia 154 93.28 High High
Neuritis 204 91.32 High High
cva 104 91.08 High High
Demyelination 66 90.00 High High
cytokine 45 89.52 High High
Disease Link Frequency Relevance Heat
Myopia 441 100.00 Very High Very High Very High
INFLAMMATION 157 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 359 99.98 Very High Very High Very High
Hydrocephalus 301 99.70 Very High Very High Very High
Neuromyelitis Optica 1783 99.60 Very High Very High Very High
Refractive Errors 225 99.44 Very High Very High Very High
Ocular Hypertension 244 99.24 Very High Very High Very High
Disease 452 99.14 Very High Very High Very High
Autoimmune Disease 179 99.08 Very High Very High Very High
Hypertrophy 26 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, in the rat eye, Wurm et al. [57] have reported an increase in AQP4 expression in the plexiform layers at the inner limiting membrane and around blood vessels between eye opening at postnatal day (P) 15 and adulthood.
Positive_regulation (increase) of Gene_expression (expression) of AQP4 in inner limiting membrane
1) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0 Pain Relevance 0
Second, as AQP4 channels are known to act as bidirectional water channels on glia cells in the cerebral cortex in the presence of edema or changes in osmoregulation [61], it is not surprising that we have seen an associated, relative increase in the expression of AQP4 on the vitreal endfeet of Müller cells in the eyes experiencing occlusion compared to fellow eyes and normal control eyes.
Positive_regulation (increase) of Gene_expression (expression) of AQP4 in cerebral cortex associated with pressure and volume under development and cerebral cortex
2) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.16 Pain Relevance 0.05
In summary, the current study reports a novel finding of increased expression of AQP4 in ON astrocytes that may be linked to cell hypertrophy.
Positive_regulation (increased) of Gene_expression (expression) of AQP4 in astrocytes associated with hypertrophy
3) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.83 Pain Relevance 0
As expected from our earlier studies that demonstrated upregulated AQP4 channel expression during form-deprivation myopia (FDM) [15], the elevation of AQP4 at the vitreo-retinal border during minus lens-induced myopic development was also seen here.
Positive_regulation (upregulated) of Gene_expression (expression) of AQP4 in lens associated with myopia
4) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.65 Pain Relevance 0
To date, there has been little consideration of the expression of proteins expected to be involved in the osmoregulatory mechanisms of fluid transfer that are required to achieve these rapid changes in ocular volume, apart from our recent reports demonstrating changes in the distribution of the ions across the retina [25,26] and an upregulation of AQP4 channel expression during the induction of form deprivation myopia [15].
Positive_regulation (upregulation) of Gene_expression (expression) of AQP4 in retina associated with myopia
5) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.42 Pain Relevance 0
The results demonstrate that the upregulation of AQP4 channel expression in the NFL is likely to be the conduit for water movement during the most rapid expansion of the vitreous chamber volume during early development of myopia.
Positive_regulation (upregulation) of Gene_expression (expression) of AQP4 in vitreous chamber associated with myopia
6) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.25 Pain Relevance 0
In particular the MCAO-induced overexpression of cerebral AQP4 can be greatly reduced by agmatine therapy, suggesting that the enhanced water movement associated with the pathophysiology of cerebral edema after transient cerebral ischemia is attenuated by agmatine.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AQP4 associated with transient ischemic attack, pressure and volume under development, middle cerebral artery infarction and ischemia
7) Confidence 0.65 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.82 Pain Relevance 0.09
As demonstrated in the current results, the MCAO-induced overexpression of cerebral AQP4 can be attenuated following systemic delivery of agmatine in rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AQP4 associated with middle cerebral artery infarction
8) Confidence 0.65 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.18 Pain Relevance 0.11
AQP4 expression is elevated in many conditions of CNS inflammation and diseases such as spongiform encephalopathy, Alzheimer's, stroke and others which do not have an infection or autoimmune component.
Positive_regulation (elevated) of Gene_expression (expression) of AQP4 associated with creutzfeldt jakob disease, inflammation, stroke, central nervous system, disease and infection
9) Confidence 0.57 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.24 Pain Relevance 0.22
Astrocytic foot processes along the pial lining also express high levels of AQP4.
Positive_regulation (levels) of Gene_expression (express) of AQP4 in foot
10) Confidence 0.57 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.52 Pain Relevance 0.14
Specific targeting of astrocytes was obtained by co-transfer of human AQP-4 autoantibody containing immunoglobulins into animals with T-cell-mediated autoimmune encephalomyelitis (EAE).
Positive_regulation (transfer) of Gene_expression (transfer) of AQP-4 in T-cell associated with multiple sclerosis and encephalitis
11) Confidence 0.55 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 1.57 Pain Relevance 0.55
Correlation between periventricular AQP4 expression and quantitative MRI
Positive_regulation (periventricular) of Gene_expression (expression) of AQP4 associated with imagery
12) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.19 Pain Relevance 0.05
This suggests that cerebral AQP4 is neuroprotective and accordingly, the increase in AQP4 expression as presented here might represent a host defense mechanism against kaolin-mediated pathology.
Positive_regulation (increase) of Gene_expression (expression) of AQP4
13) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.07 Pain Relevance 0.06
A positive more extended developmental profile for AQP4 expression has also been described in the rat brain [59], which continues to increase in volume for a longer time after birth than the eye of chick, which is required to be functional at birth and is hence closer to adult proportions at an earlier stage.
Positive_regulation (profile) of Gene_expression (expression) of AQP4 in eye
14) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0 Pain Relevance 0.03
Several studies have suggested that AQP4 levels vary depending on the insult being studied.
Positive_regulation (vary) of Gene_expression (levels) of AQP4
15) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.80 Pain Relevance 0.08
For example, while middle cerebral artery occlusion and hyperosmotic stress induced by intraperitoneal infusion of mannitol increased AQP4 in rodent brain [64,65], hypoxia evoked a marked decrease in AQP4 in astrocytes in vitro, and subsequent re-oxygenation elicited the restoration of the expression of AQP4 to its basal levels [66].
Positive_regulation (restoration) of Gene_expression (expression) of AQP4 in astrocytes associated with stress, hypoxia and middle cerebral artery infarction
16) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.74 Pain Relevance 0.07
As demonstrated in the current results, the MCAO-induced overexpression of cerebral AQP4 can be attenuated following systemic delivery of agmatine in rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AQP4 associated with middle cerebral artery infarction
17) Confidence 0.47 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.18 Pain Relevance 0.11
In particular the MCAO-induced overexpression of cerebral AQP4 can be greatly reduced by agmatine therapy, suggesting that the enhanced water movement associated with the pathophysiology of cerebral edema after transient cerebral ischemia is attenuated by agmatine.
Positive_regulation (induced) of Gene_expression (overexpression) of AQP4 associated with transient ischemic attack, pressure and volume under development, middle cerebral artery infarction and ischemia
18) Confidence 0.47 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.82 Pain Relevance 0.09
After two weeks significantly increased periventricular AQP4 expression was observed (control: 1.00, 0.88-1.2; two weeks: 1.40, 1.27-1.64, p < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of AQP4
19) Confidence 0.47 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.15 Pain Relevance 0
In contrast, AQP4 mimetics or inducers of AQP4 expression in astroglia can likely remove excess brain water from the extracellular compartment thereby facilitating the resolution of vasogenic/interstitial edema.
Positive_regulation (inducers) of Gene_expression (expression) of AQP4 in brain associated with edema
20) Confidence 0.47 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.50 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox