INT16975

Context Info Confidence 0.21 First Reported 1991 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.56 Pain Relevance 0.53

extracellular region (AKR1B10) cellular_component (AKR1B10) lysosome (AKR1B10)

Anatomy Link Frequency PVN 1 ventral 1 AKR1B10 (Homo sapiens)

Pain Link Frequency Relevance Heat spinothalamic 7 98.88 Enkephalin 2 80.56 Somatosensory cortex 1 78.00 primary somatosensory cortex 4 75.00 nociceptor 1 25.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Death 5 91.20 Nociception 3 80.88 Stress 3 75.40 Myocardial Infarction 23 38.44 Critical Illness 2 26.40 Pain 2 5.00 Coma 2 5.00 Sepsis 1 5.00 Chronic Disease 1 5.00 Mental Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

What is the quality of life or HSI of such a patient?

Gene_expression (is) of HSI

1) Confidence 0.21 Published 2008 Journal Crit Care Section Body Doc Link PMC2575575 Disease Relevance 0.25 Pain Relevance 0

Quantitative analysis of the positions and numbers of retrogradely labeled neurons and anterogradely labeled terminal fields reveal that: 1) ventral posterior lateral (VPL), ventral posterior inferior (VPI), and central lateral (CL), combined, receive 87% of spinothalamic inputs originating from the cervical enlargement; 2) these three nuclei contain over 91% of all thalamocortical neurons projecting to hSI that are likely to receive STT input; and 3) these putatively contacted neurons account for less than 24% of all thalamic projections to hSI.

Gene_expression (projecting) of hSI in ventral associated with spinothalamic

2) Confidence 0.04 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1865012 Disease Relevance 0.16 Pain Relevance 0.45

In situ hybridization revealed that novelty or HSI elevated levels of PPE hnRNA and c-fos mRNA in the PVN.

Gene_expression (levels) of HSI in PVN

3) Confidence 0.03 Published 1997 Journal Brain Res. Section Abstract Doc Link 9295199 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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