INT169759

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.78
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a1) cytoplasm (S100a1)
Anatomy Link Frequency
blood 1
muscles 1
heart muscle cell 1
Phagocyte 1
S100a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 2 99.98 Very High Very High Very High
Raphe 2 99.54 Very High Very High Very High
Locus ceruleus 1 96.48 Very High Very High Very High
sSRI 4 94.28 High High
antidepressant 3 84.28 Quite High
Serotonin 3 80.32 Quite High
monoamine 1 76.08 Quite High
imagery 13 70.32 Quite High
Inflammation 165 58.96 Quite High
Sciatic nerve 2 50.48 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 42 97.00 Very High Very High Very High
Cancer 93 92.36 High High
Targeted Disruption 48 62.52 Quite High
INFLAMMATION 174 58.96 Quite High
Disease 23 57.92 Quite High
Rheumatoid Arthritis 3 43.52 Quite Low
Juvenile Chronic Polyarthritis 3 41.76 Quite Low
Autoimmune Disease 3 38.56 Quite Low
Inflammatory Bowel Disease 3 36.08 Quite Low
Arthritis 3 23.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, raphe exposed to fluoxetine release the neurotrophic factor S100?
Localization (release) of S100 associated with raphe and fluoxetine
1) Confidence 0.43 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.78
The co-localization of EGFP fluorescence and S100 staining at nerve terminals of MG muscles transplanted from wild-type mice into EGFP mice (Figure 5) indicates that all TSCs in the muscle transplants are provided by the host.
Localization (localization) of S100 in muscles
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.11 Pain Relevance 0.03
Phagocyte specific, leaderless S100 proteins are actively secreted via an alternative pathway, bypassing the Golgi [103].
Localization (secreted) of S100 in Phagocyte
3) Confidence 0.35 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.37 Pain Relevance 0.03
S100A1 is released into the blood during ischemic periods, and extracellular S100A1 inhibits apoptosis via ERK1/2 activation [101].
Localization (released) of S100A1 in blood associated with apoptosis
4) Confidence 0.35 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.10 Pain Relevance 0.04
However, we observed that every instance of S100-positive staining co-localized with EGFP fluorescence (Figure 5C).
Localization (localized) of S100
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.12 Pain Relevance 0
S100A1 is present in the cytoplasm and nucleus – rat heart muscle cell line H9c2 is mostly nuclear, adult skeletal muscle mostly cytoplasmic.
Localization (present) of S100A1 in heart muscle cell
6) Confidence 0.33 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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