INT16976

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.08
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL36RN) extracellular region (IL36RN)
Anatomy Link Frequency
cartilage 1
peritoneal macrophages 1
IL36RN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
Pain 12 99.00 Very High Very High Very High
intrathecal 4 97.58 Very High Very High Very High
allodynia 6 94.92 High High
Hyperalgesia 2 94.36 High High
Arthritis 4 91.36 High High
Thermal hyperalgesia 3 90.28 High High
Lasting pain 1 88.00 High High
Osteoarthritis 8 87.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Cancer 3 99.20 Very High Very High Very High
Immune System Diseases 3 99.08 Very High Very High Very High
Pain 12 99.00 Very High Very High Very High
Necrosis 3 98.96 Very High Very High Very High
Disease 20 98.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 98.16 Very High Very High Very High
Neuropathic Pain 11 94.92 High High
Hyperalgesia 5 94.36 High High
Pressure And Volume Under Development 1 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its unique pharmacological activity involves inhibition of interleukin 1 and cartilage-degrading enzymes.
Negative_regulation (inhibition) of interleukin 1 in cartilage
1) Confidence 0.49 Published 1993 Journal Rev Rhum Ed Fr Section Abstract Doc Link 8118457 Disease Relevance 0.80 Pain Relevance 0.30
Examination of carbenoxolone's effects on intrathecal human immunodeficiency virus type 1 gp120 showed that blockade of pain facilitation might result, at least in part, via suppression of interleukin-1 and, in turn, interleukin-6.
Negative_regulation (suppression) of interleukin-1 associated with pain, acquired immune deficiency syndrome or hiv infection and intrathecal
2) Confidence 0.19 Published 2004 Journal J Pain Section Abstract Doc Link 15501197 Disease Relevance 1.88 Pain Relevance 1.71
Compounds 3a and 4a, tested in vitro on lipopolysaccharide (LPS)-stimulated rat peritoneal macrophages, were seen to be active in the inhibition of prostaglandin E2 (PGE2) production and interleukin-1 activity.
Negative_regulation (inhibition) of interleukin-1 in peritoneal macrophages
3) Confidence 0.17 Published 1991 Journal J Pharm Sci Section Abstract Doc Link 1865334 Disease Relevance 0.27 Pain Relevance 0.12
Immune modification using local steroids and disease-modifying antirheumatic drugs, such as hydroxychloroquine, are known to inhibit inflammatory cells and cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor, which are responsible for pain and tissue damage.
Negative_regulation (inhibit) of interleukin-1 associated with pain, necrosis, inflammation, cancer, disease and cytokine
4) Confidence 0.04 Published 2005 Journal J Reprod Med Section Abstract Doc Link 16130848 Disease Relevance 1.47 Pain Relevance 1.11
Rhein, the active metabolite of diacerein, inhibits interleukin-1 activity.
Negative_regulation (inhibits) of interleukin-1
5) Confidence 0.03 Published 1997 Journal Drugs Section Abstract Doc Link 9010651 Disease Relevance 0.13 Pain Relevance 0.06
The effectiveness of interleukin-1 blockade in a variety of disorders has resulted in a marked reduction in suffering for many of these patients.



Negative_regulation (blockade) of interleukin-1
6) Confidence 0.02 Published 2010 Journal F1000 Med Rep Section Abstract Doc Link PMC2948378 Disease Relevance 0.53 Pain Relevance 0

General Comments

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