INT169762

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
Mir16-1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 6 99.00 Very High Very High Very High
sSRI 8 98.32 Very High Very High Very High
Serotonin 6 95.04 Very High Very High Very High
fluoxetine 4 84.24 Quite High
Raphe 4 79.44 Quite High
Locus ceruleus 2 66.48 Quite High
monoamine 2 46.08 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Regulation (target) of microRNA-16 in neurons
1) Confidence 0.22 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.62
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Regulation (target) of miR-16 in neurons
2) Confidence 0.22 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.63

General Comments

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