INT169765

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.21
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
neurons 2
synovium 2
lymph node 1
Mir16-1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 133 99.44 Very High Very High Very High
antidepressant 6 98.08 Very High Very High Very High
sSRI 8 97.40 Very High Very High Very High
Serotonin 6 94.12 High High
Osteoarthritis 2 87.32 High High
fluoxetine 4 86.00 High High
Raphe 4 81.20 Quite High
cytokine 36 72.76 Quite High
Locus ceruleus 2 68.24 Quite High
Arthritis 128 55.80 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 139 99.44 Very High Very High Very High
Osteoarthritis 2 87.32 High High
Chronic Lymphoid Leukemia 12 77.48 Quite High
Diffuse Large B-cell Lymphoma 168 62.72 Quite High
Repression 2 61.28 Quite High
B-cell Lymphoma 81 58.56 Quite High
Lymphatic System Cancer 366 56.08 Quite High
Arthritis 124 55.80 Quite High
Genetic Translocation 3 27.52 Quite Low
Syndrome 18 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Gene_expression (expressed) of miR-16 in neurons
1) Confidence 0.63 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.63
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Gene_expression (expressed) of miR-16 in neurons
2) Confidence 0.49 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.63
More recently, elevated expression of miR-146a, miR-155, miR-132, miR-16, but not miR-let-7a expression was found in RA synovium [112] with elevated miR-146a levels also found in circulating RA monocytes.
Gene_expression (expression) of miR-16 in synovium associated with rheumatoid arthritis
3) Confidence 0.02 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.14 Pain Relevance 0.60
More recently, elevated expression of miR-146a, miR-155, miR-132, miR-16, but not miR-let-7a expression was found in RA synovium [112] with elevated miR-146a levels also found in circulating RA monocytes.
Gene_expression (expression) of miR-16 in synovium associated with rheumatoid arthritis
4) Confidence 0.02 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.14 Pain Relevance 0.60
No correlation was found between miR-15a and miR-16 expression levels and 13q14 deletion in the blood CLL samples [37].
Gene_expression (expression) of miR-16 in blood
5) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.31 Pain Relevance 0
Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples.
Gene_expression (expression) of miR-16 in blood
6) Confidence 0.00 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.31 Pain Relevance 0
Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples.
Gene_expression (expression) of miR-16 in lymph node
7) Confidence 0.00 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.31 Pain Relevance 0

General Comments

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