INT169768

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
neurons 2
Slc6a4 (Mus musculus)
Mir16-1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 6 99.40 Very High Very High Very High
sSRI 8 98.72 Very High Very High Very High
Serotonin 6 95.44 Very High Very High Very High
fluoxetine 4 84.24 Quite High
Raphe 4 79.44 Quite High
Locus ceruleus 2 66.48 Quite High
monoamine 2 46.08 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
SERT Binding (target) of microRNA-16 in neurons
1) Confidence 0.33 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.63
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
SERT Binding (target) of miR-16 in neurons
2) Confidence 0.33 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.63

General Comments

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