INT169779

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.20
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sdhb) mitochondrion (Sdhb) oxidoreductase activity (Sdhb)
Anatomy Link Frequency
pupil 1
Sdhb (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 3 94.48 High High
headache 3 94.12 High High
ischemia 285 78.60 Quite High
adenocard 159 50.00 Quite Low
agonist 42 25.76 Quite Low
Inflammation 96 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 24 100.00 Very High Very High Very High
Ganglion Cysts 3 96.44 Very High Very High Very High
Migraine Disorders 3 94.48 High High
Cv Unclassified Under Development 270 78.60 Quite High
Targeted Disruption 18 65.76 Quite High
Necrosis 15 54.48 Quite High
Body Weight 9 34.52 Quite Low
INFLAMMATION 87 5.00 Very Low Very Low Very Low
Injury 33 5.00 Very Low Very Low Very Low
Acute Renal Failure 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that light activation of ipRGCs may regulate physiological functions such as sleep/wake cycles in preterm and neonatal infants.
Positive_regulation (activation) of ipRGCs
1) Confidence 0.67 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20855606 Disease Relevance 0.06 Pain Relevance 0.12
We conclude that light activation of melanopsin ipRGCs is necessary and sufficient for negative phototaxis.
Positive_regulation (activation) of ipRGCs
2) Confidence 0.58 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20855606 Disease Relevance 0.12 Pain Relevance 0.13
Direct light stimulation of ipRGCs can regulate many nonimage-forming visual functions such as photoentrainment of circadian rhythms and pupil responses, and can intensify migraine headache in adults.
Positive_regulation (stimulation) of ipRGCs in pupil associated with migraine and headache
3) Confidence 0.45 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20855606 Disease Relevance 0.19 Pain Relevance 0.19
These studies revealed prompt and selective induction of the A2BAR transcript following renal IP (approximately 6-fold induction 60 min after IP, p < 0.05, Figure 9C).
Positive_regulation (induction) of IP
4) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.07
These studies revealed prompt and selective induction of the A2BAR transcript following renal IP (approximately 6-fold induction 60 min after IP, p < 0.05, Figure 9C).
Positive_regulation (induction) of IP
5) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.07
Consistent with previous work showing selective A2BAR induction with vascular hypoxia [24] or myocardial IP [28], these studies reveal induction of A2BAR transcript and protein with renal IP treatment.


Positive_regulation (induction) of IP associated with hypoxia
6) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.28 Pain Relevance 0.06

General Comments

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