INT169785

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.35
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
neurons 2
duodenum 2
stomach 2
cumulus cells 1
brain 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 32 98.52 Very High Very High Very High
long-term potentiation 116 95.44 Very High Very High Very High
Glutamate 8 90.08 High High
agonist 45 87.52 High High
qutenza 8 74.84 Quite High
antagonist 15 70.68 Quite High
Deafferentation 4 69.60 Quite High
alcohol 15 62.72 Quite High
nMDA receptor 8 46.08 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peptic Ulcer 4 90.00 High High
Targeted Disruption 76 79.24 Quite High
Ulcers 4 75.00 Quite High
Acid Reflux 4 53.68 Quite High
Fever 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Rupture 6 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Localization (secretion) of EP3 in duodenum
1) Confidence 0.57 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.37 Pain Relevance 0.34
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Localization (secretion) of EP3 in duodenum
2) Confidence 0.50 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.30 Pain Relevance 0.32
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of EP3 in neurons
3) Confidence 0.40 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.14
This involves interesting and efficient trafficking of EP2 and EP3, both of which are located at the postsynaptic sites in the neurons of the visual cortex.
Localization (located) of EP3 in cortex
4) Confidence 0.40 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.52
This suggests the implication of EP2 and EP3 in the physiological functions of these regions of the brain.
Localization (implication) of EP3 in brain
5) Confidence 0.40 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.27
Previously, Segi and colleagues used in situ hybridization to successfully localize mRNA for EP2 and EP4 (but not EP1 and EP3) to cumulus granulosa cells within mouse periovulatory follicles [9].
Neg (not) Localization (localize) of EP3 in follicles
6) Confidence 0.37 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Immunocytochemical analysis of the hippocampal neurons in culture revealed that EP2 highly colocalized with synaptophysin (71.0%), but partially with PSD-95 (14.2%), whereas EP3 partially colocalized with PSD-95 (45.3%) or synaptophysin (38.7%) (Zhu et al. 2005).
Localization (colocalized) of EP3 in neurons
7) Confidence 0.35 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.11
More recently, EP2, EP3 and EP4 mRNA and proteins were localized to mouse cumulus cells [10].
Localization (localized) of EP3 in cumulus cells
8) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
EP1 and EP3 were not observed in mouse oocytes (not shown), similar to results obtained with monkey oocytes.
Neg (not) Localization (observed) of EP3 in oocytes
9) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.13
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Localization (secretion) of EP3 in stomach
10) Confidence 0.19 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.37 Pain Relevance 0.34
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Localization (secretion) of EP3 in stomach
11) Confidence 0.17 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.30 Pain Relevance 0.32

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