INT169788

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.11
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger4) plasma membrane (Ptger4) signal transducer activity (Ptger4)
Anatomy Link Frequency
duodenum 1
stomach 1
theca 1
Ptger4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 28 84.92 Quite High
qutenza 4 72.24 Quite High
antagonist 61 68.08 Quite High
cerebral cortex 1 67.40 Quite High
Deafferentation 2 67.00 Quite High
Paracetamol 2 65.04 Quite High
Inflammation 6 56.88 Quite High
COX-2 inhibitor 10 41.72 Quite Low
aspirin 8 34.92 Quite Low
cINOD 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 94.32 High High
Cancer 83 94.00 High High
Peptic Ulcer 2 87.40 High High
Intestinal Cancer 2 86.32 High High
Pancreatic Cancer 84 86.08 High High
Ulcers 2 75.00 Quite High
Carcinoma 1 68.52 Quite High
Lung Cancer 3 63.48 Quite High
INFLAMMATION 8 56.88 Quite High
Acid Reflux 2 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Negative_regulation (inhibition) of EP4 in duodenum
1) Confidence 0.51 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.36 Pain Relevance 0.33
EP2 and EP4 are reported to couple exclusively with G?
Negative_regulation (reported) of EP4
2) Confidence 0.28 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Recently, theca cells have also been suggested as a target for PGE2 action, with detection of mRNA for EP2, EP3, and EP4 in bovine theca [32] and EP2 mRNA in mouse theca cells [9].
Negative_regulation (detection) of EP4 in theca
3) Confidence 0.24 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Negative_regulation (inhibition) of EP4 in stomach
4) Confidence 0.17 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.36 Pain Relevance 0.33
PGE2 receptors are a family of G-protein-coupled receptors, namely, EP1, EP2, EP3, and EP4 [68].
Negative_regulation (family) of EP4
5) Confidence 0.08 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.26 Pain Relevance 0.03
PGE2 exerts its autocrine/paracrine action by binding to either of four main subtypes of GPCR (EP1, EP2, EP3 and EP4) to mobilize intracellular calcium and inositol 1,4,5-trisphosphate (InsP) via Gq/11 (EP1/EP3) or increase cAMP accumulation via G?
Negative_regulation (subtypes) of EP4
6) Confidence 0.02 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.13 Pain Relevance 0.13

General Comments

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