INT169792

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.00
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger4) plasma membrane (Ptger4) signal transducer activity (Ptger4)
Ptger4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 70 100.00 Very High Very High Very High
antagonist 59 98.40 Very High Very High Very High
Inflammation 19 63.40 Quite High
qutenza 2 61.08 Quite High
Deafferentation 1 55.84 Quite High
chemokine 1 44.08 Quite Low
cytokine 7 40.80 Quite Low
Dopamine 20 5.00 Very Low Very Low Very Low
ketamine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 99.22 Very High Very High Very High
Inflammatory Breast Neoplasms 34 99.10 Very High Very High Very High
Metastasis 3 93.68 High High
Breast Cancer 15 92.52 High High
Ganglion Cysts 17 89.32 High High
Hyperplasia 2 88.16 High High
Reprotox - General 1 3 80.24 Quite High
Peptic Ulcer 1 76.24 Quite High
Hypoxia 3 75.44 Quite High
Ulcers 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the healing-promoting effect is associated with the stimulation of angiogenesis via an increase in VEGF expression (EP4).
Positive_regulation (increase) of Gene_expression (expression) of EP4
1) Confidence 0.60 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.28 Pain Relevance 0.21
VEGF increase due to EP2 and EP4 agonists
Positive_regulation (due) of Gene_expression (agonists) of EP4 associated with agonist
2) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.16 Pain Relevance 0.23
in cAMP production, consistent with the expression of EP4, PGE2 had no effect on PPAR?
Neg (no) Positive_regulation (on) of Gene_expression (expression) of EP4
3) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0.30 Pain Relevance 0.04
IBC tumor cells with high Cox-2 expression also express high levels of EP4 receptor (Fig. 5C).
Positive_regulation (levels) of Gene_expression (express) of EP4 receptor associated with inflammatory breast neoplasms and cancer
4) Confidence 0.08 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 1.03 Pain Relevance 0.17
As FPS cells also express basal levels of EP2 and EP4 receptor (but not detectable EP1 or EP3 receptor), we found that PGE2 and to a much lesser extent PGF2?
Positive_regulation (levels) of Gene_expression (express) of EP4
5) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.18

General Comments

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