INT169798

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.70
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rapgef3) cytoplasm (Rapgef3)
Rapgef3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 10 98.16 Very High Very High Very High
Inflammation 12 95.36 Very High Very High Very High
Hyperalgesia 20 94.32 High High
nav1.8 2 73.60 Quite High
IPN 2 57.24 Quite High
hyperexcitability 2 51.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 20 94.20 High High
INFLAMMATION 8 66.56 Quite High
Inflammatory Pain 2 57.24 Quite High
Nociception 2 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, GRK2 deficiency increased 8-pCPT-induced activation of the downstream effector of Epac, Rap1, and extracellular signal-regulated kinase (ERK).
Positive_regulation (activation) of Epac
1) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20861385 Disease Relevance 1.01 Pain Relevance 1.42
A reduction in the cellular level of GRK2 enhances activation of the Epac-Rap1 pathway.
Positive_regulation (activation) of Epac-Rap1
2) Confidence 0.39 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20861385 Disease Relevance 0.68 Pain Relevance 1.14

General Comments

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