INT169818

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch3) plasma membrane (Notch3) nucleus (Notch3)
Notch3 (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 1 57.40 Quite High
Disease Link Frequency Relevance Heat
Cadasil 8 99.56 Very High Very High Very High
Cerebrovascular Disease 1 85.24 High High
Dementia 1 63.28 Quite High
Cognitive Disorder 1 62.04 Quite High
Stroke 1 58.88 Quite High
Epilepsy 1 58.12 Quite High
Headache 1 57.40 Quite High
Disease 1 55.96 Quite High
Syndrome 1 53.24 Quite High
Leukoencephalopathies 1 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, these experimental models provide new opportunities to explore the molecular and physiological mechanisms of CADASIL, and address the fundamental question of whether CADASIL phenotype represents loss of NOTCH3 function or gain of a novel and pathological function.
Spec (whether) Negative_regulation (loss) of NOTCH3 associated with cadasil
1) Confidence 0.38 Published 2010 Journal Stroke Section Abstract Doc Link 20876488 Disease Relevance 1.19 Pain Relevance 0.06

General Comments

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