INT169838

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 2 87.44 High High
Pain 2 79.60 Quite High
TRP channel 2 57.92 Quite High
Disease Link Frequency Relevance Heat
Pain 2 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV2 desensitization was not altered in whole-cell recordings in the presence of calmodulin inhibitors or on coexpression of mutant calmodulin but was sensitive to changes in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)), suggesting a role of membrane PIP(2) in TRPV2 desensitization.
Neg (not) Regulation (altered) of Negative_regulation (desensitization) of TRPV2
1) Confidence 0.22 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.08 Pain Relevance 0.12
TRPV2 desensitization was not altered in whole-cell recordings in the presence of calmodulin inhibitors or on coexpression of mutant calmodulin but was sensitive to changes in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)), suggesting a role of membrane PIP(2) in TRPV2 desensitization.
Regulation (sensitive) of Negative_regulation (desensitization) of TRPV2
2) Confidence 0.22 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

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