INT169862

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 13.61
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
plasma 1
lateral 1
midbrain 1
microglia 1
neural 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 21 100.00 Very High Very High Very High
midbrain 20 100.00 Very High Very High Very High
qutenza 10 99.98 Very High Very High Very High
Hippocampus 17 97.88 Very High Very High Very High
Opioid 2 93.68 High High
Spinal cord 10 92.12 High High
palliative 1 90.00 High High
Dopamine 83 86.80 High High
medulla 5 86.08 High High
imagery 98 78.20 Quite High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 627 100.00 Very High Very High Very High
Cancer 577 100.00 Very High Very High Very High
Cv Unclassified Under Development 15 100.00 Very High Very High Very High
Hodgkin's Disease 4 99.76 Very High Very High Very High
Targeted Disruption 12 99.32 Very High Very High Very High
Neurodegenerative Disease 45 99.08 Very High Very High Very High
Langerhans-cell Histiocytosis 5 98.80 Very High Very High Very High
Metastasis 101 98.48 Very High Very High Very High
Hypoxia 4 98.32 Very High Very High Very High
Infection 63 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that DLC-1 might be a NPC-related tumour suppressor gene affected by aberrant promoter methylation and gene deletion [25].
Regulation (affected) of NPC associated with cancer and nasopharynx cancer
1) Confidence 0.53 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.63 Pain Relevance 0
Previous molecular studies on NPC have focused on DNA and chromosomal levels, but few on
Regulation (few) of NPC associated with nasopharynx cancer
2) Confidence 0.39 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.89 Pain Relevance 0
effectiveness on NPC [136].
Regulation (effectiveness) of NPC associated with nasopharynx cancer
3) Confidence 0.39 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.21 Pain Relevance 0
As NPCs tend to infiltrate and spread towards these normal organs, the irradiation target volumes in NPC are very irregular.
Regulation (irregular) of NPC associated with nasopharynx cancer
4) Confidence 0.33 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2848311 Disease Relevance 0.54 Pain Relevance 0.13
Conventional 2 dimensional (2D) radiotherapy for NPC depends heavily on large lateral opposing fields.
Regulation (depends) of NPC in lateral associated with nasopharynx cancer
5) Confidence 0.33 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2848311 Disease Relevance 1.38 Pain Relevance 0.11
These results might suggest that the recurrent NPC be highly responsive to chemotherapy but survival with chemotherapy alone is poor.
Regulation (responsive) of NPC associated with nasopharynx cancer
6) Confidence 0.20 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2966947 Disease Relevance 0.85 Pain Relevance 0.09
This strategy revealed a number of putative TSGs that were down-regulated in NPC and also located at LOH loci.
Regulation (regulated) of NPC associated with nasopharynx cancer
7) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.39 Pain Relevance 0.18
Additional investigations will be required on patient plasma samples - both NPC and controls - in order to address 2 questions: 1) Are concentrations of BART miRNAs consistently greater in the plasma of NPC patients by comparison with healthy carriers and patients bearing non-NPC tumors ?
Regulation (controls) of NPC in plasma associated with cancer and nasopharynx cancer
8) Confidence 0.07 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.26 Pain Relevance 0
Exclusion of SDF-1 or EFNB1 also had the largest effect on generation of midbrain NPC as indicated by 86% and 85% decrease in Msx1+ colonies, respectively, as compared to treatment with all four factors (Fig. 3I).
Regulation (effect) of NPC in midbrain associated with midbrain
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.15
Not surprisingly, cell cycle machinery play a role in regulating the fate of NPC (Herrup and Yang 2007).
Regulation (regulating) of NPC
10) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.76 Pain Relevance 0.03
The aim of this study was to determine whether capsaicin affected murine-derived cerebellar multi-potent neural progenitor cells (NPC) or adult hippocampal neurogenesis in vivo.
Spec (whether) Regulation (affected) of NPC in neural associated with qutenza and neurodegenerative disease
11) Confidence 0.02 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.52 Pain Relevance 0.81
A biopsy is required for final diagnosis, treatment being different for NPC, non-Hodgkin lymphoma (NHL), LCH and metastatic disease.


Regulation (different) of NPC associated with langerhans-cell histiocytosis, nasopharynx cancer, hodgkin's disease and metastasis
12) Confidence 0.02 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2950273 Disease Relevance 2.28 Pain Relevance 0.13
NPC proliferation in animals with hippocampal ischemia was not affected by the presence of ED-1+ activated microglia.
Neg (not) Regulation (affected) of NPC in microglia associated with ischemia
13) Confidence 0.02 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2868803 Disease Relevance 0.81 Pain Relevance 0.18
Although, application of the SOCE inhibitor 2-APB had no effect in A2B5+ NPC (Figure 4), the knock-down of TRPC5 with siRNA significantly blocked the SOCE (Figure 7D).
Neg (no) Regulation (effect) of NPC associated with targeted disruption
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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