INT169863

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.85
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP10) extracellular space (MMP10) extracellular region (MMP10)
proteinaceous extracellular matrix (MMP10)
Anatomy Link Frequency
plaques 1
brain 1
MMP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 88 100.00 Very High Very High Very High
Inflammation 21 99.14 Very High Very High Very High
cva 1 91.04 High High
cINOD 2 72.16 Quite High
ischemia 2 64.80 Quite High
imagery 13 50.00 Quite Low
Angina 8 14.08 Low Low
COX-2 inhibitor 19 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.14 Very High Very High Very High
Atherosclerotic Plaque 9 97.28 Very High Very High Very High
Stroke 9 95.12 Very High Very High Very High
Pressure And Volume Under Development 1 91.60 High High
Hemorrhage 1 91.04 High High
Brain Injury 1 84.80 Quite High
Injury 10 75.20 Quite High
Adhesions 3 71.04 Quite High
Rupture 4 67.92 Quite High
Brain Hemorrhage 1 65.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, CRP and MMP-10 colocalized within the endothelial layer and macrophage-rich areas in advanced atherosclerotic plaques.
Localization (colocalized) of MMP-10 in plaques associated with atherosclerotic plaque
1) Confidence 0.46 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.77 Pain Relevance 0.26
Although the exact cellular source of MMPs remains unknown, brain endothelium, astrocytes, neurons, and inflammatory-activated cells, such as neutrophils, may release MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, and/or MMP-13.
Localization (release) of MMP-10 in brain associated with inflammation and metalloproteinase
2) Confidence 0.45 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20955435 Disease Relevance 1.08 Pain Relevance 0.53
The pro and active gelatinases (MMP-2 and MMP-9), collagenases (MMP-1 and MMP-13), and stromelysins (MMP-3 and MMP-10) levels released in the media were measured using a Quantikine colorimetric and Fluorokine fluorometric enzyme immunoassay (EIA) kit (R&D Systems Minneapolis, MN) using the manufacturer's instructions.
Localization (released) of MMP-10 associated with metalloproteinase
3) Confidence 0.10 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0 Pain Relevance 0.45

General Comments

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