INT169874

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.64
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
tail 4
DRG 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 132 97.88 Very High Very High Very High
Inflammatory mediators 16 97.88 Very High Very High Very High
Inflammation 88 97.04 Very High Very High Very High
dorsal root ganglion 5 96.16 Very High Very High Very High
Hippocampus 20 91.12 High High
central sensitization 18 88.40 High High
hyperexcitability 12 87.52 High High
nociceptor 3 86.80 High High
IPN 36 86.72 High High
Neuropathic pain 8 84.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 126 97.88 Very High Very High Very High
Ganglion Cysts 5 96.16 Very High Very High Very High
Nociception 56 92.24 High High
Inflammatory Pain 36 86.72 High High
Neuropathic Pain 8 84.64 Quite High
Pain 25 73.20 Quite High
Disease 52 50.00 Quite Low
Mental Disorders 3 50.00 Quite Low
Eating Disorder 1 49.32 Quite Low
Depression 22 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that PKA modulation of K(Na) channels does not happen at the level of channel gating but arises from the internal trafficking of Slack channels from DRG membranes.
Neg (not) Positive_regulation (happen) of Gene_expression (modulation) of PKA in DRG associated with dorsal root ganglion
1) Confidence 0.38 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20962237 Disease Relevance 0.62 Pain Relevance 0.55
The PKA activity seems to be regulated by the activity of PDE1 in the basal condition owing to the high affinity of PDE1 for Ca2+/CaM (Kd ?
Positive_regulation (for) of Gene_expression (activity) of PKA
2) Confidence 0.28 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The main findings from these simulations suggest that the presence of the PKA–PP2A–phosphoThr75 loop causes increased formation of free PKAc as well as phosphoThr34 if a dopamine input is paired with a transient calcium elevation.
Positive_regulation (increased) of Gene_expression (presence) of PKA associated with dopamine
3) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.07
This effect of dibutyryl cAMP is not dependent on activation of the PKA pathway, as the addition of forskolin does not result in a rebound in PrPSc levels (Fig. 4A).
Positive_regulation (activation) of Gene_expression (pathway) of PKA
4) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0 Pain Relevance 0
CaMKII may indirectly mediate the phosphorylation of GluR1 at the Serine845 site through adenylate cyclase and PKA, since the Ca2+-calmodulin complex can stimulate adenylate cyclase, and subsequently activate more cAMP production and PKA activity.
Positive_regulation (through) of Gene_expression (production) of PKA
5) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.32 Pain Relevance 0.54
CaMKII may indirectly mediate the phosphorylation of GluR1 at the Serine845 site through adenylate cyclase and PKA, since the Ca2+-calmodulin complex can stimulate adenylate cyclase, and subsequently activate more cAMP production and PKA activity.
Positive_regulation (activate) of Gene_expression (production) of PKA
6) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.31 Pain Relevance 0.50
In this paper, co-transfection with the PKA catalytic subunit (a constitutive active form of PKA) or CREB expression vector significantly induces the vasopressin gene promoter activity, as well as cAMP stimulators.
Positive_regulation (transfection) of Gene_expression (transfection) of PKA
7) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.03
Although previous results revealed that MAPK activation is not dependent upon PKA activation, we were interested in whether or not production of inflammatory mediators initiated by ?
Neg (not) Positive_regulation (upon) of Gene_expression (activation) of PKA associated with inflammatory mediators
8) Confidence 0.07 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.19 Pain Relevance 0.10
Although previous results revealed that MAPK activation is not dependent upon PKA activation, we were interested in whether or not production of inflammatory mediators initiated by ?
Neg (not) Positive_regulation (dependent) of Gene_expression (activation) of PKA associated with inflammatory mediators
9) Confidence 0.07 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.19 Pain Relevance 0.10
In addition, from our work in the pituitary field, and the work of others, we know that multiple estrogens induce activation of MAPKs.129,130 The estrogenic activation of other kinases likely to act on DAT’s N-terminal tail have yet to be investigated;93,131 these include PKA, PKG, the subtypes of PKC (?
Positive_regulation (include) of Gene_expression (subtypes) of PKA in tail
10) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.13
is subject to regulation by both direct prostacyclin/PKA and NO/PKG-inhibition mediated through their respective phosphorylation of Ser329 and Ser331 within the unique C-tail domain of TP?
Positive_regulation (direct) of Gene_expression (/) of PKA in tail
11) Confidence 0.03 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

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