INT169875

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.07
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ercc1) chromosome organization (Ercc1) nucleus (Ercc1)
cytoplasm (Ercc1)
Anatomy Link Frequency
liver 1
Ercc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 82.92 Quite High
anesthesia 1 21.52 Low Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cockayne Syndrome 2 99.78 Very High Very High Very High
Aging 22 98.82 Very High Very High Very High
Tetraploidy 4 92.80 High High
Intervertebral Disk Degeneration 10 90.32 High High
Nicotine Addiction 2 88.40 High High
Injury 2 86.44 High High
Genetic Predisposition To Disease 2 86.12 High High
Pain 2 82.92 Quite High
Hutchinson-gilford Progeria Syndrome 2 75.00 Quite High
Apoptosis 2 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we examined progression of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1-XPF (Ercc1(-/?)
Negative_regulation (deficiency) of ERCC1 associated with aging and cockayne syndrome
1) Confidence 0.43 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20973062 Disease Relevance 1.34 Pain Relevance 0.08
Here we examined progression of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1-XPF (Ercc1(-/?)
Negative_regulation (deficiency) of Ercc1 associated with aging and cockayne syndrome
2) Confidence 0.43 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20973062 Disease Relevance 1.34 Pain Relevance 0.08
A deficiency of DNA repair protein ERCC1 in mice results in accelerated polyploidization rates in liver [23].
Negative_regulation (deficiency) of repair protein ERCC1 in liver
3) Confidence 0.05 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1940261 Disease Relevance 0.39 Pain Relevance 0

General Comments

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