INT169907

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 31
Disease Relevance 21.95
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
RB neurons 2
pituitary 2
retina 1
hepatocyte 1
colon 1
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 19 99.72 Very High Very High Very High
imagery 266 99.64 Very High Very High Very High
COX2 5 99.36 Very High Very High Very High
ischemia 82 97.88 Very High Very High Very High
cytokine 36 85.28 High High
agonist 44 81.48 Quite High
palliative 3 77.48 Quite High
Somatosensory cortex 22 71.08 Quite High
Inflammation 14 66.56 Quite High
Spinal cord 78 56.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 227 100.00 Very High Very High Very High
Repression 22 100.00 Very High Very High Very High
Retinoblastoma 19 100.00 Very High Very High Very High
Pituitary Cancer 178 99.84 Very High Very High Very High
Colon Cancer 29 99.84 Very High Very High Very High
Epstein-barr Virus 54 99.82 Very High Very High Very High
Carcinoma 50 99.72 Very High Very High Very High
Adenoma 36 99.72 Very High Very High Very High
Cancer 749 99.66 Very High Very High Very High
Pressure And Volume Under Development 369 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By co-immunoprecipitating HMGA2 and pRB in pituitary adenomas developed by HMGA2 mice, we demonstrated the interaction between the two proteins occurring in the tumor.
Gene_expression (immunoprecipitating) of pRB in pituitary associated with cancer and pituitary cancer
1) Confidence 0.60 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.45 Pain Relevance 0
More recently, a new mechanism of pRB-mediated E2F1 repression has been suggested in addition to this one.
Gene_expression (repression) of pRB associated with repression
2) Confidence 0.60 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.48 Pain Relevance 0
g/ml were p21/Cip (Pharmingen Inc, San Diego, CA, USA), pRb (IF8), p107 (SD9), p130 (C-20), E2F-1 (C-20), E2F-4(C-20) and PCNA (C-20) (Santa Cruz Biotechnology Inc, Santa Cruz, CA, USA).
Gene_expression (/) of pRb
3) Confidence 0.59 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.07 Pain Relevance 0
The phosphorylated H1 and pRb bands were scanned and quantitated densitometrically using a Phosphoimager (Molecular Dynamics, Sunnyvle, CA, USA).


Gene_expression (bands) of pRb in bands
4) Confidence 0.59 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
Consistent with RB photoactivation not occurring in response to two-photon imaging, in animals with RB injection that received no photoactivation (by green light), we did not observe any degradation of dendritic morphology over a 6-h period (see Figure S1) [15].
Gene_expression (injection) of RB associated with imagery
5) Confidence 0.58 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.33 Pain Relevance 0.23
Furthermore, RB photoactivation and induction of clotting by a focused laser even within 15 ?
Gene_expression (photoactivation) of RB associated with coagulation disorder
6) Confidence 0.58 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.33 Pain Relevance 0.18
Rb retina-specific knockout
Gene_expression (knockout) of Rb in retina associated with targeted disruption
7) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.71 Pain Relevance 0
In particular, the retinal periphery shows the full effect of Rb loss, whereas there is almost no ?
Gene_expression (loss) of Rb
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.54 Pain Relevance 0
Sequencing of p16ink4a, k-ras and Rb cDNA
Gene_expression (cDNA) of Rb
9) Confidence 0.38 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.67 Pain Relevance 0
The adenoma was found to express the Rb gene while the carcinoma displayed no Rb genetic expression, indicating the carcinogenic potential of loss-of-function Rb mutations.
Gene_expression (express) of Rb associated with adenoma and carcinoma
10) Confidence 0.35 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.55 Pain Relevance 0
The adenoma was found to express the Rb gene while the carcinoma displayed no Rb genetic expression, indicating the carcinogenic potential of loss-of-function Rb mutations.
Neg (no) Gene_expression (expression) of Rb associated with adenoma and carcinoma
11) Confidence 0.35 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.59 Pain Relevance 0
Deletions of this gene and of the retinoblastoma 1 gene are often found in malignant gliomas and melanomas [23].
Gene_expression (Deletions) of retinoblastoma 1 gene associated with melanoma, retinoblastoma and glioma
12) Confidence 0.34 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.79 Pain Relevance 0.06
When 2MeSADP (100 µM) was included with the RB dye, the average size of the brain lesions was significantly reduced to 0.86 mm3±0.19 (n?
Gene_expression (dye) of RB in brain
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.09 Pain Relevance 0
Specifically, RB-induced lesions in both control and test mice were permitted to expand to 0.95±0.17×105 µm2 (n?
Gene_expression (lesions) of RB-induced
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.49 Pain Relevance 0.07
Additionally, the average size of the RB-induced lesions at 24 hours was essentially unchanged at 5.43±0.50×105 µm2 (n?
Gene_expression (lesions) of RB-induced
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.20 Pain Relevance 0.04
As observed with CD40 fluorescence labeling, the mean area of the RB-induced lesion increased from 2.07 mm3±0.24 (n?
Gene_expression (lesion) of RB-induced
16) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.15 Pain Relevance 0.03
Control experiments demonstrated that in the presence of dox (no tTA expression), RB-induced lesions in GFAP-tTA-mtEcoRI mice were indistinguishable from wildtype mice (Fig.
Gene_expression (lesions) of RB-induced
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.25 Pain Relevance 0
Temporal imaging of perivascular astrocytes immediately after a single RB-induced photothrombosis revealed rapid swelling with the average size of the cell soma increasing over 6-fold within 3 hours, from 63±15 µm2 at rest to 382±61 µm2 (mean ± SD, n?
Gene_expression (photothrombosis) of RB-induced in soma associated with pressure and volume under development and imagery
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.07 Pain Relevance 0.12
The RB concentration was 20 mg/ml for large lesions (?
Gene_expression (concentration) of RB
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.18 Pain Relevance 0.19
Crossbreeding of Rb (+/-) animals with PTTG1 transgenic animals showed enlarged pituitary glands and a 3.5-fold increase in the frequency of tumors originating from?
Gene_expression (animals) of Rb in pituitary glands associated with targeted disruption and cancer
20) Confidence 0.16 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.28 Pain Relevance 0.03

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