INT169908

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.68
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
apoptotic cell 2
nucleus 2
proximal 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 19 85.68 High High
COX-2 inhibitor 10 52.64 Quite High
Inflammation 25 42.92 Quite Low
addiction 2 32.00 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Eae 12 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 389 100.00 Very High Very High Very High
Death 148 100.00 Very High Very High Very High
Cancer 120 92.96 High High
Skin Cancer 7 91.04 High High
Ovarian Cancer 1 82.16 Quite High
Pancreatic Cancer 31 80.48 Quite High
Breast Cancer 45 77.20 Quite High
Malignant Neoplastic Disease 7 57.28 Quite High
Repression 18 55.84 Quite High
Disease 262 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A truncated Sox17 isoform (t-Sox17), which lacks most of the HMG box and cannot bind DNA [34], did not affect cyclin D1 promoter activity (Fig. 6C), indicating that activation of cyclin D1-luciferase reporters by Sox17 requires DNA binding.
Localization (reporters) of cyclin D1-luciferase
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
A well-conserved consensus Sox binding sequence was identified in cyclin D1 proximal promoter, located at approximately ?
Localization (located) of cyclin D1 in proximal
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Cyclin D1, E and A associated kinase activities decreased by four-, four-, and fivefold, respectively, in TM10 cells compared with control on SAHA treatment, whereas only cyclin D1 and A associated kinase activities decreased (2.2- and 2.6-fold, respectively) in SAHA treated TM2H cells compared with control (Fig. 6).
Localization (decreased) of Cyclin D1
3) Confidence 0.28 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.06 Pain Relevance 0
The question remains whether COX-2 induced PGE2 can directly regulate cyclin D1 or other network of cyclins, cyclin-dependent kinases (CDKs) or CDK inhibitors.
Localization (network) of cyclin D1
4) Confidence 0.16 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.94 Pain Relevance 0.11
Cyclin D1 might be the cause of apoptotic cell death when overexpressed.25,26 Alternatively, increase of Cyclin D1 in BxPC-3 cells may be a feedback response to drug-induced cell cycle arrest.
Localization (increase) of Cyclin D1 in apoptotic cell associated with apoptosis and death
5) Confidence 0.07 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.84 Pain Relevance 0
Cyclin D1 might be the cause of apoptotic cell death when overexpressed.25,26 Alternatively, increase of Cyclin D1 in BxPC-3 cells may be a feedback response to drug-induced cell cycle arrest.
Localization (increase) of Cyclin D1 in apoptotic cell associated with apoptosis and death
6) Confidence 0.07 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.84 Pain Relevance 0
Also p27Kip1, together with p21Cip1, has been shown to promote nuclear import of cognate cyclin D1/Cdk4, therefore the import of cyclins, that do not have obvious nuclear import signals, like cyclin D in mammals and Clb5 and Clb6 in yeast, appear to be imported into the nucleus piggy-backed on cargos (the complex cyclin/Cdk/Cki) that contains a protein (the Cki) with a NLS [23,24].
Localization (import) of cyclin D1 in nucleus
7) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0 Pain Relevance 0
Also p27Kip1, together with p21Cip1, has been shown to promote nuclear import of cognate cyclin D1/Cdk4, therefore the import of cyclins, that do not have obvious nuclear import signals, like cyclin D in mammals and Clb5 and Clb6 in yeast, appear to be imported into the nucleus piggy-backed on cargos (the complex cyclin/Cdk/Cki) that contains a protein (the Cki) with a NLS [23,24].
Localization (import) of cyclin D1 in nucleus
8) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0 Pain Relevance 0

General Comments

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