INT169916

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
muscle cells 1
CER 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 6 10.36 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 250 97.80 Very High Very High Very High
Adenocarcinoma 52 96.84 Very High Very High Very High
Apoptosis 34 86.64 High High
Myotonic Dystrophy 8 75.00 Quite High
Breast Cancer 6 75.00 Quite High
Cataract 4 55.44 Quite High
Arrhythmias 2 Under Development 1 55.00 Quite High
Hypopituitarism 11 53.88 Quite High
Frailty 3 53.48 Quite High
Death 12 40.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perinuclear localization of p21 was detected in only few TM2H cells (p53 null) when both cell lines were immunostained for p21, whereas p21 was localized in both cytoplasmic and nuclear compartments in TM10 cells (p53 wt) (data not shown).
Localization (localization) of p21
1) Confidence 0.31 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
Perinuclear localization of p21 was detected in only few TM2H cells (p53 null) when both cell lines were immunostained for p21, whereas p21 was localized in both cytoplasmic and nuclear compartments in TM10 cells (p53 wt) (data not shown).
Localization (localized) of p21
2) Confidence 0.31 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
Mutant DMPK-mediated effect on subcellular localization, and defective phosphorylation of cytoplasmic CUG-BP1, have additionally been linked to defective translation of p21 and MEF2A in DM1, possibly explaining delayed differentiation of DM1 muscle cells.
Localization (translation) of p21 in muscle cells
3) Confidence 0.20 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.40 Pain Relevance 0
Thereby, the rapid release of PTX and the slower release of CER would impart the temporal controlled release profile that results in enhanced efficacy against MDR cancer.
Localization (release) of controlled in CER associated with cancer
4) Confidence 0.06 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 0.47 Pain Relevance 0
A polymer-blend nanoparticle system was engineered to incorporate temporally controlled sequential release of the combination drug payload.
Localization (release) of controlled
5) Confidence 0.05 Published 2008 Journal Molecular Pharmaceutics Section Abstract Doc Link PMC2646668 Disease Relevance 0.39 Pain Relevance 0

General Comments

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