INT169918

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.64
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
DBTRG-05MG 3
RG2 3
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 8 92.12 High High
imagery 18 90.12 High High
Angina 18 70.60 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 533 99.08 Very High Very High Very High
Retinoblastoma 2 94.32 High High
Brain Tumor 66 94.24 High High
Malignant Neoplastic Disease 43 93.76 High High
Apoptosis 217 93.04 High High
Glioblastoma 228 90.88 High High
Stress 9 79.24 Quite High
Hyperplasia 4 78.04 Quite High
Cv General 3 Under Development 18 70.60 Quite High
Breast Cancer 17 68.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SAHA also resulted in the inhibition of G1/S kinase activities and, consequently, hypophosphorylation of the three pRb pocket proteins, which led to G1 cell growth arrest and dramatic decreases in DNA synthesis in both cell lines.
Negative_regulation (inhibition) of Phosphorylation (hypophosphorylation) of pRb
1) Confidence 0.37 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.05 Pain Relevance 0
attenuation of pRb phosphorylation, resulting in inhibition of cell
Negative_regulation (attenuation) of Phosphorylation (phosphorylation) of pRb
2) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.82 Pain Relevance 0
Therefore, the decrease in phosphorylated Rb should be due to a BP-triggered expression of the cdk inhibitors, which decreases the activities of the cyclin/cdk complex.
Negative_regulation (decrease) of Phosphorylation (phosphorylated) of Rb
3) Confidence 0.03 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.55 Pain Relevance 0
This compound, isolated from marine sponges, is a potent anti-cancer marine steroid that causes G1 arrest by down-regulation of Rb phosphorylation (Fukuoka et al. 2000).
Negative_regulation (regulation) of Phosphorylation (phosphorylation) of Rb associated with cancer
4) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.69 Pain Relevance 0
The p21 protein binds to the cyclin/cdk complex, resulting in the inhibition of the G1 to S phase transition (Dobashi et al. 2003) via the abrogation of Rb phosphorylation by the cyclin/cdk complex.
Negative_regulation (abrogation) of Phosphorylation (phosphorylation) of Rb
5) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.56 Pain Relevance 0
However, levels of phosphorylated Rb proteins were decreased after BP treatment in DBTRG-05MG and DBTRG 8401 cells; in RG2 cells, the levels were decreased (0.8-fold) at 1.5 h, with phosphorylated proteins undetectable as early as 3 h after BP treatment (Fig. 2a).
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of Rb in RG2
6) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.57 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Rb in DBTRG-05MG
7) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.71 Pain Relevance 0.16
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Negative_regulation (decrease) of in RG2 Phosphorylation (phosphorylation) of Rb in DBTRG-05MG
8) Confidence 0.01 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.71 Pain Relevance 0.16

General Comments

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