INT169921

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
lungs 2
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 13 96.56 Very High Very High Very High
Targeted Disruption 36 94.88 High High
Cancer 98 86.24 High High
Hyperglycemia 1 78.48 Quite High
Polycystic Kidney Disease 62 77.76 Quite High
Diabetes Mellitus 1 71.40 Quite High
Hypoglycemia 1 67.20 Quite High
Repression 14 65.76 Quite High
Cyst 32 64.32 Quite High
Colon Cancer 3 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, Sox17 decreased the expression of p15, p21, and p57 in adult mouse lungs, and inhibited TGF-?
Negative_regulation (decreased) of Gene_expression (expression) of p21 in lungs
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.24 Pain Relevance 0
The p21 expression level decreased by 50% in TM10 cells upon SAHA treatment (Fig. 7A).
Negative_regulation (decreased) of Gene_expression (expression) of p21
2) Confidence 0.22 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
The translocation of Id2 in cells with mutated polycystins is associated with downregulation of p21 expression, leading to an increase in CDK2 activity and cell cycle progression (Fig. 3).
Negative_regulation (downregulation) of Gene_expression (expression) of p21
3) Confidence 0.07 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.25 Pain Relevance 0
In their experiments, they suggested that the absence of PTTG1 may allow expression of p21, which causes cell cycle arrest.
Spec (may) Negative_regulation (allow) of Gene_expression (expression) of p21
4) Confidence 0.04 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.89 Pain Relevance 0

General Comments

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