INT169928

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) cell cycle (E2f1)
DNA binding (E2f1) transcription factor binding (E2f1) cytoplasm (E2f1)
E2f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 89.92 High High
cva 1 14.36 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Bladder Cancer 10 93.48 High High
INFLAMMATION 28 89.92 High High
Pituitary Cancer 54 88.52 High High
Cancer 41 79.20 Quite High
Death 5 60.00 Quite High
Retinoblastoma 5 51.28 Quite High
Targeted Disruption 22 49.92 Quite Low
Prolactinoma 6 38.56 Quite Low
Benign Tumor 2 31.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of E2F1 hyperacetylation in the absence of HMGA2 overexpression would suggest the involvement of other proteins acting with the same or similar mechanism of HMGA2 protein, or alternatively other mechanisms that eventually lead to an increase in E2F1 acetylation and subsequent activation.



Positive_regulation (increase) of Gene_expression (acetylation) of E2F1
1) Confidence 0.48 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.21 Pain Relevance 0
More recently, a new mechanism of pRB-mediated E2F1 repression has been suggested in addition to this one.
Positive_regulation (mediated) of Gene_expression (repression) of E2F1 associated with repression
2) Confidence 0.48 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.48 Pain Relevance 0
To further investigate the effect of SAHA on inhibition of DNA synthesis, we examined E2F-1 as a key mediator for G1 ?
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (examined) of E2F-1
3) Confidence 0.34 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
NF-kappaB was replaced largely by E2F1 in concert with gene activation during the early stage (12 h) of serum stimulation.
Positive_regulation (activation) of Gene_expression (replaced) of E2F1
4) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.60 Pain Relevance 0.13

General Comments

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