INT169935

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Context Info
Confidence 0.19
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.46
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Eri1) RNA binding (Eri1) rRNA binding (Eri1)
nucleus (Eri1) intracellular (Eri1) cytoplasm (Eri1)
Anatomy Link Frequency
MCF-7 2
oocytes 2
Eri1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 8 88.84 High High
Central nervous system 4 30.72 Quite Low
Dopamine 15 25.24 Quite Low
Neurotransmitter 3 24.88 Low Low
medulla 3 17.52 Low Low
Potency 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 3 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 145 100.00 Very High Very High Very High
Embryonic Lethality 3 98.24 Very High Very High Very High
Body Weight 21 91.48 High High
Cytomegalovirus Infection 9 91.08 High High
Cancer 9 61.48 Quite High
Death 21 59.28 Quite High
Disease 21 53.20 Quite High
Contagious Ecthyma 9 33.76 Quite Low
Parkinson's Disease 15 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Line #8 expressed the RNAi transgene at a higher level than line #35 and was used for further experiments.
Positive_regulation (level) of Gene_expression (expressed) of RNAi
1) Confidence 0.19 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.81 Pain Relevance 0
Generation of RNAi transgenic mice
Positive_regulation (Generation) of Gene_expression (Generation) of RNAi associated with targeted disruption
2) Confidence 0.19 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.19 Pain Relevance 0
In transgenic mice, an shRNA against Id4 gene induces developmental defects in kidney 12; silencing of Fgfr2 gene causes embryonic lethality 13; inhibition of Msy2 gene expression in oocytes results in reduced fertility 33; and silencing of Sod2 gene by transgenic RNAi leads to SOD2 dysfunction that results in severe consequences resembling the phenotypes of Sod2 gene knockout 14.
Positive_regulation (leads) of Gene_expression (silencing) of RNAi in oocytes associated with targeted disruption and embryonic lethality
3) Confidence 0.19 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 1.16 Pain Relevance 0
Effects of the plasmid based RNAI protocol against AGRP
Positive_regulation (based) of Gene_expression (protocol) of RNAI
4) Confidence 0.05 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC134599 Disease Relevance 0.23 Pain Relevance 0.09
It has been reported that upregulation of KIAA0128 gene expression, which has been implicated in activation of histone mRNA synthesis, was related to cell cycle arrest in MCF-7 cells after treatment with SAHA [43].
Positive_regulation (activation) of Gene_expression (synthesis) of histone mRNA in MCF-7
5) Confidence 0.03 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.06 Pain Relevance 0

General Comments

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