INT169937

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Context Info
Confidence 0.01
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (E2f2) cell cycle (E2f2) DNA binding (E2f2)
transcription factor binding (E2f2)
Anatomy Link Frequency
pituitary 1
intestine 1
E2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 1 74.12 Quite High
cINOD 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 27 96.00 Very High Very High Very High
Cancer 14 85.76 High High
Targeted Disruption 12 82.40 Quite High
Obesity 2 81.64 Quite High
Adenoma 4 79.24 Quite High
Repression 6 77.76 Quite High
Retinoblastoma 3 74.48 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 74.44 Quite High
Disease 3 74.12 Quite High
Gastrointestinal Disease 3 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of free E2F/DP heterodimers to E2F sites generally activates transcription of proteins required for G1 ?
E2F Binding (Binding) of
1) Confidence 0.01 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.15 Pain Relevance 0
CCNA1 belongs to the cyclin family, and binds to important cell cycle regulators such as E2F, Rb, CDK2 and p21, but its abundance in the intestine is low [34].
E2F Binding (binds) of in intestine
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.39 Pain Relevance 0.04
Conversely, an increase in E2F "free" DNA binding was always observed in pituitaries from single mutant HMGA2 mice even before the appearance of the pituitary tumour.
E2F Binding (binding) of in pituitary associated with pituitary cancer
3) Confidence 0.01 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.83 Pain Relevance 0

General Comments

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