INT169940

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 90.72 High High
Pyramidal cell 1 63.08 Quite High
Inflammation 9 61.36 Quite High
cytokine 8 46.24 Quite Low
chemokine 1 41.20 Quite Low
Inflammatory mediators 2 33.52 Quite Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 100.00 Very High Very High Very High
Disease 127 94.40 High High
Aging 5 93.28 High High
Stress 33 91.84 High High
Cancer 11 87.60 High High
Carcinoma 1 79.04 Quite High
Acute Erythroblastic Leukemia 2 76.36 Quite High
Cognitive Disorder 16 64.32 Quite High
Thrombocytopenia 1 61.52 Quite High
INFLAMMATION 15 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified a novel mechanism for SAHA in cell growth arrest through inhibition in DNA synthesis, concomitant with significant increases in the nuclear localization of pRb-2/p130 associated with E2F-4, decreases in key molecules in DNA synthesis (E2F-1, PCNA and p21), and increases in histone H3 and H4 protein and acetylation levels.
Positive_regulation (increases) of Localization (localization) of pRb
1) Confidence 0.61 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.57 Pain Relevance 0.05
induces upregulation of cdk4/6, phosphorylation of the retinoblastoma protein pRb/107, release of Rb from the transcription factor complex E2F-DP and activation of E2F-mediated trascription of genes required for S phase transition, but these events occur in a p53-independent manner [214].
Positive_regulation (induces) of Localization (release) of Rb associated with retinoblastoma
2) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.17 Pain Relevance 0.06

General Comments

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