INT169945

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.75
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 33 56.36 Quite High
Potency 4 8.96 Low Low
cINOD 12 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 67 99.40 Very High Very High Very High
Retinoblastoma 5 99.28 Very High Very High Very High
Repression 11 88.16 High High
Apoptosis 37 85.16 High High
Obesity 143 83.60 Quite High
Hyperplasia 4 82.28 Quite High
Pituitary Cancer 27 77.16 Quite High
Breast Cancer 5 72.68 Quite High
Squamous Cell Carcinoma 1 48.96 Quite Low
Prolactinoma 3 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, in proliferating cells, pRB is phosphorylated at multiple sites by cyclin-dependent kinases [31,32], resulting in the release of E2F1 and, consequently, transcriptional activation of its target genes [33].
Positive_regulation (resulting) of Phosphorylation (phosphorylated) of pRB
1) Confidence 0.41 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.44 Pain Relevance 0
SAHA treatment resulted in G1 cell growth arrest in TM10 and TM2H cell lines, concomitant with the profound increase in dephosphorylation of the three pRb pocket proteins.
Positive_regulation (increase) of Phosphorylation (dephosphorylation) of pRb
2) Confidence 0.41 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.09 Pain Relevance 0
retinoblastoma tumor suppressor gene product, and phosphorylated pRB induces
Positive_regulation (induces) of Phosphorylation (phosphorylated) of pRB associated with cancer and retinoblastoma
3) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.84 Pain Relevance 0
This inhibitory complex is adipogenesis stage-dependent, such that earlier in adipogenesis (i.e., at Day 4), hyperphosphorylation of RB minimizes complex formation (thus enabling maximal PPAR?
Positive_regulation (enabling) of Phosphorylation (hyperphosphorylation) of RB
4) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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