INT169957

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.94
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
5A1 1
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 46 98.84 Very High Very High Very High
cocaine 292 93.76 High High
local anesthetic 1 40.64 Quite Low
Inflammation 9 37.80 Quite Low
sodium channel 1 26.64 Quite Low
Central nervous system 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 99.72 Very High Very High Very High
Endometriosis 48 98.84 Very High Very High Very High
Hyperoxia 1 97.68 Very High Very High Very High
Breast Cancer 2 84.32 Quite High
Apoptosis 50 83.92 Quite High
Stress 32 78.44 Quite High
Necrosis 9 77.16 Quite High
Cancer 29 76.80 Quite High
Sprains And Strains 16 58.24 Quite High
INFLAMMATION 11 37.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, other groups [4,20] have reported no differences between normal and eutopic endometria from women with endometriosis, probably due to the use of different techniques and the detection of proliferating cell nuclear antigen (PCNA), a nuclear protein restricted to S phase.
Transcription (detection) of PCNA associated with endometriosis
1) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 0.32 Pain Relevance 0.09
Activation of the p53-p21 pathway has been implicated in hyperoxia-induced inhibition of G1/S progression, through suppression of CDK activity and subsequent repression of cyclin A2 transcription and inactivation of PCNA [34,49].
Transcription (transcription) of PCNA associated with repression and hyperoxia
2) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.33 Pain Relevance 0.47
The pECFP-PCNA and the HcRed-PCNA are described in (49) and (50), respectively.


Transcription (described) of pECFP-PCNA
3) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
The pECFP-PCNA and the HcRed-PCNA are described in (49) and (50), respectively.


Transcription (described) of HcRed-PCNA
4) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
PCNA mRNA expression and mRNA expression of the PPAR?
Transcription (expression) of PCNA
5) Confidence 0.16 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.21 Pain Relevance 0
The sections were washed 3× in PBS and incubated with a mouse anti PCNA monoclonal antibody (clone PC10, Zymed Laboratories Inc., CA, USA) or Cleaved Caspase 3 (Asp175 5A1, Cell Signaling Inc.
Transcription (antibody) of PCNA in 5A1
6) Confidence 0.13 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.08 Pain Relevance 0
In the untreated cells, the cytoplasmic PCNA protein levels in TM10 and TM2H cell lines were similar, but the level of PCNA in the nuclear fraction was fourfold higher in TM2H cells compared with TM10 cells (Fig. 7B).
Transcription (level) of PCNA
7) Confidence 0.06 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0

General Comments

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