INT16996

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2011
Negated 22
Speculated 2
Reported most in Abstract
Documents 113
Total Number 115
Disease Relevance 85.61
Pain Relevance 22.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
Anatomy Link Frequency
neutrophil 12
plasma cells 7
T cells 6
synovium 5
pallidum 2
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 5820 100.00 Very High Very High Very High
intrathecal 1 99.98 Very High Very High Very High
cytokine 203 99.32 Very High Very High Very High
cocaine 5 99.24 Very High Very High Very High
Inflammation 596 99.04 Very High Very High Very High
Spinal cord 10 98.80 Very High Very High Very High
Inflammatory response 3 98.72 Very High Very High Very High
Pain 98 98.32 Very High Very High Very High
Infliximab 367 96.16 Very High Very High Very High
spinal inflammation 182 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 5833 100.00 Very High Very High Very High
Urological Neuroanatomy 131 100.00 Very High Very High Very High
Trepenoma Infection 4 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 42 99.90 Very High Very High Very High
Autoimmune Hepatitis 1020 99.84 Very High Very High Very High
Lumbar Puncture Related Headaches 1 99.84 Very High Very High Very High
Disease 1275 99.76 Very High Very High Very High
Biliary Liver Cirrhosis 48 99.76 Very High Very High Very High
Sickle Cell Anemia 2 99.64 Very High Very High Very High
Meningitis 11 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using monoclonal antibodies, we showed that PR3 is expressed on the plasma membrane of neutrophil granulocytes and monocytes; thus, PR3 autoantigens are accessible for circulating antibodies.
Gene_expression (expressed) of PR3 in neutrophil
1) Confidence 0.75 Published 1991 Journal Am. J. Kidney Dis. Section Abstract Doc Link 1867175 Disease Relevance 1.46 Pain Relevance 0.16
The presence of c-ANCA, demonstration of vasculitis, and depositions of immunoglobulin G (IgG) and fibrinogen in the vessel walls of pachymeninges of the patient confirmed an immune-mediated cause of the vasculitis.
Gene_expression (presence) of c-ANCA associated with increased venous pressure under development
2) Confidence 0.75 Published 2001 Journal J Neuroimaging Section Abstract Doc Link 11198530 Disease Relevance 0.70 Pain Relevance 0.16
Autoantibodies including p- and c-ANCA were negative.
Neg (negative) Gene_expression (negative) of c-ANCA
3) Confidence 0.75 Published 2002 Journal Neuropathology Section Abstract Doc Link 12564771 Disease Relevance 1.18 Pain Relevance 0.26
Although proteinase 3 (PR3)-ANCA was negative, we diagnosed Wegener's granulomatosis (WG) based on the following ELK criteria: upper airways (E); saddle nose, chronic otitis media and exophthalmos, lungs (L); alveolar hemorrhage, and kidneys (K); occult-blood and protein positive urine.
Neg (negative) Gene_expression (negative) of proteinase 3 in upper associated with otitis media, ocular toxicity (including many sub-types) and cva
4) Confidence 0.68 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 19455961 Disease Relevance 0.99 Pain Relevance 0.30
Although proteinase 3 (PR3)-ANCA was negative, we diagnosed Wegener's granulomatosis (WG) based on the following ELK criteria: upper airways (E); saddle nose, chronic otitis media and exophthalmos, lungs (L); alveolar hemorrhage, and kidneys (K); occult-blood and protein positive urine.
Neg (negative) Gene_expression (negative) of PR3 in upper associated with otitis media, ocular toxicity (including many sub-types) and cva
5) Confidence 0.68 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 19455961 Disease Relevance 0.99 Pain Relevance 0.29
Cytoplasm-labeling antineutrophil cytoplasmic autoantibodies (cANCA) directed against proteinase 3 (PR3) are detected in the sera of approximately 90% of patients.
Gene_expression (detected) of cANCA
6) Confidence 0.67 Published 2007 Journal Presse Med Section Abstract Doc Link 17363211 Disease Relevance 0.10 Pain Relevance 0.03
In particular, the associations between SNP rs324987 and ACPA-negative RA (p?
Gene_expression (rs324987) of ACPA associated with rheumatoid arthritis
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 0.82 Pain Relevance 0.36
However, the precise causes of the disease and of the initial immune process leading to cANCA production remain unknown.
Gene_expression (production) of cANCA associated with disease
8) Confidence 0.60 Published 2007 Journal Presse Med Section Abstract Doc Link 17363211 Disease Relevance 0.41 Pain Relevance 0.08
Cytoplasm-labeling antineutrophil cytoplasmic autoantibodies (cANCA) directed against proteinase 3 (PR3) are detected in the sera of approximately 90% of patients.
Gene_expression (detected) of PR3
9) Confidence 0.60 Published 2007 Journal Presse Med Section Abstract Doc Link 17363211 Disease Relevance 0.09 Pain Relevance 0.03
However, the cytoplasmic-antineutrophil cytoplasmic antibody (c-ANCA) test was negative.
Neg (negative) Gene_expression (negative) of c-ANCA
10) Confidence 0.59 Published 2003 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 14661558 Disease Relevance 0.55 Pain Relevance 0.07
On a follow-up MRI after 3 months, the magnetic resonance changes were less apparent, i. e., the hypertrophic pachymeningitis was resolving; C-ANCA were now no longer detectable in the cerebrospinal fluid.
Neg (no) Gene_expression (detectable) of C-ANCA in cerebrospinal fluid
11) Confidence 0.58 Published 2005 Journal Med. Klin. (Munich) Section Body Doc Link 15834530 Disease Relevance 0.13 Pain Relevance 0
[A patient with both cocaine-induced nasal septum destruction and antibodies against anti-neutrophil cytoplasmic antibodies (ANCA); potential confusion with Wegener's disease].
Gene_expression (antibodies) of ANCA in neutrophil associated with disease, confusion and cocaine
12) Confidence 0.58 Published 2007 Journal Ned Tijdschr Geneeskd Section Title Doc Link 18019218 Disease Relevance 0.93 Pain Relevance 0.30
MBT sandals produce a statistically significant increase in frontal and sagittal plane ranges of motion of the subtalar and ankle joint complex during gait.
Gene_expression (produce) of MBT in ankle joint
13) Confidence 0.57 Published 2011 Journal J Foot Ankle Res Section Body Doc Link PMC3024926 Disease Relevance 0.08 Pain Relevance 0
The management of ANCA was performed in 42 patients with variant primary glomerulonephritis with crescents formation or sclerotic glomerulonephritis, 5 of them show positive, appeared as a pattern of P-ANCA.
Gene_expression (pattern) of P-ANCA in crescents associated with renal disease
14) Confidence 0.56 Published 1993 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 8404317 Disease Relevance 1.16 Pain Relevance 0.09
In the laboratory findings, inflammatory reactions were seen, and anti-neutrophil cytoplasmic antibody (PR 3-ANCA) was positive.
Gene_expression (positive) of PR 3-ANCA in neutrophil associated with inflammation
15) Confidence 0.55 Published 2003 Journal Ryumachi Section Abstract Doc Link 12692988 Disease Relevance 0.55 Pain Relevance 0.18
Laboratory evaluation revealed an eosinophil count of 30,450/microliter, and P-antineutrophil cytoplasmic antibody (ANCA) was positive.
Gene_expression (positive) of ANCA in eosinophil
16) Confidence 0.53 Published 2001 Journal Rinsho Shinkeigaku Section Abstract Doc Link 11968751 Disease Relevance 1.24 Pain Relevance 0.36
A recent subtractive cDNA cloning study in rats demonstrated an unexpected increase in expression of the proteinase inhibitor, cystatin C in the spinal cord during acute peripheral inflammation, suggesting this protein may be involved in the pathogenesis of persistent pain.
Gene_expression (expression) of proteinase in spinal cord associated with pain, inflammation, lasting pain and spinal cord
17) Confidence 0.51 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.64 Pain Relevance 0.64
Two forms exist: cytoplasmic (cANCA) of which the principal target is protease-3 (PR3) and perinuclear (pANCA) which is directed against myeloperoxidase (MPO).
Gene_expression (directed) of PR3 associated with urological neuroanatomy
18) Confidence 0.49 Published 2008 Journal Head Face Med Section Body Doc Link PMC2531096 Disease Relevance 0.82 Pain Relevance 0
1-antitrypsin deficiency.37 Single nucleotide polymorphisms in the IL-2 receptor have been associated with systemic lupus erythematosus (SLE) and also with AAV,38 and CTLA4 and PTPN22 have been identified as susceptibility loci in AAV.39 Patients with AAV and PR3-ANCA have higher neutrophil membrane expression of PR3 which is genetically determined and related to relapse.40 Finally, analysis of leucocyte gene expression profiles in patients has demonstrated that ANCA signature genes are expressed on neutrophils and can be differentiated from healthy donors and patients with SLE.41 However, no clear link with major histocompatibility antigens has so far been demonstrated.


Gene_expression (expressed) of ANCA in neutrophils associated with vasculitis, systemic lupus erythematosus and recurrence
19) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.52 Pain Relevance 0
1-antitrypsin deficiency.37 Single nucleotide polymorphisms in the IL-2 receptor have been associated with systemic lupus erythematosus (SLE) and also with AAV,38 and CTLA4 and PTPN22 have been identified as susceptibility loci in AAV.39 Patients with AAV and PR3-ANCA have higher neutrophil membrane expression of PR3 which is genetically determined and related to relapse.40 Finally, analysis of leucocyte gene expression profiles in patients has demonstrated that ANCA signature genes are expressed on neutrophils and can be differentiated from healthy donors and patients with SLE.41 However, no clear link with major histocompatibility antigens has so far been demonstrated.


Gene_expression (expression) of PR3 in neutrophils associated with vasculitis, systemic lupus erythematosus and recurrence
20) Confidence 0.47 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.54 Pain Relevance 0

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