INT169963

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1, Rbl2) cell cycle (Rb1, Rbl2) DNA binding (Rb1, Rbl2)
nucleolus (Rbl2) enzyme binding (Rb1) cell division (Rb1)
Anatomy Link Frequency
epithelial cell 2
Rb1 (Mus musculus)
Rbl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 97.48 Very High Very High Very High
Cancer 9 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Acute Erythroblastic Leukemia 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Bladder Cancer 1 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 1 5.00 Very Low Very Low Very Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.



Positive_regulation (induction) of pRb Binding (interaction) of p130 in epithelial cell associated with repression
1) Confidence 0.33 Published 2001 Journal Breast Cancer Res Section Title Doc Link PMC13923 Disease Relevance 0.10 Pain Relevance 0

General Comments

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