INT16997

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 33.44
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
Anatomy Link Frequency
spinal 2
neutrophils 2
monocytes 1
spine 1
lymphoid tissue 1
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1088 99.84 Very High Very High Very High
headache 4 98.92 Very High Very High Very High
cytokine 36 98.46 Very High Very High Very High
fibrosis 12 97.88 Very High Very High Very High
Inflammation 231 97.20 Very High Very High Very High
Restless leg syndrome 4 96.80 Very High Very High Very High
backache 7 96.68 Very High Very High Very High
cva 19 96.56 Very High Very High Very High
intrathecal 3 94.96 High High
imagery 14 94.84 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 65 100.00 Very High Very High Very High
Renal Disease 37 99.98 Very High Very High Very High
Meningitis 13 99.98 Very High Very High Very High
Rheumatoid Arthritis 1111 99.84 Very High Very High Very High
Interstitial Lung Diseases 16 99.84 Very High Very High Very High
Infection 60 99.72 Very High Very High Very High
Disease 414 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 73 99.52 Very High Very High Very High
Hepatitis C Virus Infection 43 99.50 Very High Very High Very High
Hepatitis 21 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is important to be a wore that crescentic glomerulonephritis associated with P-ANCA can develop in patients with interstitial pneumonia.
P-ANCA Binding (associated) of associated with interstitial lung diseases and renal disease
1) Confidence 0.48 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 9234635 Disease Relevance 1.00 Pain Relevance 0.13
This case shows that interstitial pneumonia can be associated with P-ANCA.
P-ANCA Binding (associated) of associated with interstitial lung diseases
2) Confidence 0.48 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 9234635 Disease Relevance 0.83 Pain Relevance 0.13
We demonstrated that 95% of C-ANCA-positive sera react with proteinase 3 (PR3 or myeloblastin).
PR3 Binding (react) of
3) Confidence 0.47 Published 1991 Journal Am. J. Kidney Dis. Section Abstract Doc Link 1867175 Disease Relevance 1.50 Pain Relevance 0.17
In particular, the associations between SNP rs324987 and ACPA-negative RA (p?
ACPA Binding (associations) of associated with rheumatoid arthritis
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 0.83 Pain Relevance 0.36
In summary, we have provided here initial evidence that NPSR1 SNPs associate with ACPA-negative RA and disease activity.
ACPA Binding (associate) of associated with rheumatoid arthritis and disease
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 0.85 Pain Relevance 0.19
Cerebral and oculorhinal manifestations of a limited form of Wegener's granulomatosis with c-ANCA-associated vasculitis.
c-ANCA Binding (granulomatosis) of associated with increased venous pressure under development
6) Confidence 0.36 Published 2001 Journal J Neuroimaging Section Title Doc Link 11198530 Disease Relevance 0.69 Pain Relevance 0.15
Upon cytokine priming of neutrophils, this enzyme translocates to the cell surface, where PR3-ANCAs can interact with their antigens and activate neutrophils [49].
PR3 Binding (interact) of in neutrophils associated with cytokine
7) Confidence 0.35 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 1.09 Pain Relevance 0.29
WG is usually associated with PR3-ANCA.
PR3 Binding (associated) of
8) Confidence 0.34 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 2.79 Pain Relevance 0.11
Silicosis may affect multiple organ involvement associated with P-ANCA.
P-ANCA Binding (associated) of associated with occupational lung diseases
9) Confidence 0.34 Published 1999 Journal Ryumachi Section Abstract Doc Link 10695408 Disease Relevance 1.94 Pain Relevance 0.23
Previous reports have demonstrated the association of MPO-ANCA with rapidly progressive NCGN, microscopic polyarteritis, and occasionally pulmonary hemorrhage recognized as pulmonary-renal syndrome.
MPO-ANCA Binding (association) of associated with syndrome, renal disease, urological neuroanatomy and cva
10) Confidence 0.30 Published 1996 Journal Ryumachi Section Abstract Doc Link 9122827 Disease Relevance 1.48 Pain Relevance 0.23
However, the present case suggests the possibility that another disease subset may also be associated with MPO-ANCA, which is characterized by interstitial pneumonitis and slowly progressive glomerulonephritis.
MPO-ANCA Binding (associated) of associated with interstitial lung diseases, renal disease, urological neuroanatomy and disease
11) Confidence 0.30 Published 1996 Journal Ryumachi Section Abstract Doc Link 9122827 Disease Relevance 1.58 Pain Relevance 0.13
There is a strong and specific association of WG with presence of anti-neutrophil cytoplasmic antibodies (ANCA) to a defined target antigen, proteinase 3 (PR3-ANCA), which is present within primary azurophil granules of neutrophils and lysozymes of monocytes [48].
proteinase 3 Binding (association) of in monocytes
12) Confidence 0.29 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 1.20 Pain Relevance 0.21
[Hypertrophic pachymeningitis, glomerulonephritis and P-ANCA associated small vessel vasculitis].
P-ANCA Binding (associated) of associated with meningitis, renal disease, headache and increased venous pressure under development
13) Confidence 0.28 Published 2007 Journal Medicina (B Aires) Section Title Doc Link 17593600 Disease Relevance 0.67 Pain Relevance 0.19
Additional investigations, including ANA, ANCA, and serological testing for syphilis were negative.
ANCA Binding (investigations) of associated with trepenoma infection
14) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350140 Disease Relevance 0.95 Pain Relevance 0.29
Two forms exist: cytoplasmic (cANCA) of which the principal target is protease-3 (PR3) and perinuclear (pANCA) which is directed against myeloperoxidase (MPO).
PR3 Binding (is) of associated with urological neuroanatomy
15) Confidence 0.27 Published 2008 Journal Head Face Med Section Body Doc Link PMC2531096 Disease Relevance 0.81 Pain Relevance 0
ANCA bind to the cell surface by both Fc receptor engagement13 and (FabÂ’)2 binding,14 thereby activating the cell.
ANCA Binding (bind) of
16) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 0.92 Pain Relevance 0.17
Rheumatoid factor versus ACPA in RA
ACPA Binding (Rheumatoid factor) of associated with rheumatoid arthritis
17) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.14 Pain Relevance 0.30
The introduction of tests recognizing 'anti-citrullinated protein antibodies' (ACPA) has caused a revolution in rheumatology.
ACPA Binding (recognizing) of
18) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297585 Disease Relevance 0.54 Pain Relevance 0.19
[A case of hypertrophic spinal pachymeningitis associated with MPO-ANCA].
MPO-ANCA Binding (associated) of in spinal associated with meningitis and urological neuroanatomy
19) Confidence 0.19 Published 2002 Journal Rinsho Shinkeigaku Section Title Doc Link 12710088 Disease Relevance 1.07 Pain Relevance 0.25
This is the first report of hypertrophic pachymeningitis associated with MPO-ANCA localized exclusively in the spine.
MPO-ANCA Binding (associated) of in spine associated with meningitis and urological neuroanatomy
20) Confidence 0.19 Published 2002 Journal Rinsho Shinkeigaku Section Abstract Doc Link 12710088 Disease Relevance 1.12 Pain Relevance 0.24

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