INT169996

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
joint 2
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 16 99.40 Very High Very High Very High
antagonist 3 99.02 Very High Very High Very High
Arthritis 59 76.72 Quite High
Inflammation 8 26.48 Quite Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 16 99.40 Very High Very High Very High
Apoptosis 121 98.96 Very High Very High Very High
Cancer 9 94.60 High High
Arthritis 20 76.72 Quite High
Neurodegenerative Disease 8 76.56 Quite High
Synovitis 1 70.12 Quite High
Experimental Arthritis 39 67.04 Quite High
Disease 21 65.88 Quite High
Lymphoproliferative Disease 1 59.84 Quite High
Suicidal Behaviour 27 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly (see discussion), concurrent exposure to the estrogenic antagonist 4-hydroxytamoxifen did not prevent the estrogen-induced reduction in Fas.


Positive_regulation (induced) of Negative_regulation (reduction) of Fas associated with antagonist
1) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.09
B

activation [14,15,16], a relative deficiency of functional Fas ligand in the RA joint [17], and expression of antiapoptotic molecules, such as bcl-2 [3] and sentrin [18].

Positive_regulation (activation) of Negative_regulation (deficiency) of Fas in joint associated with rheumatoid arthritis
2) Confidence 0.20 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.42 Pain Relevance 0.19

General Comments

This test has worked.

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