INT169997

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 37
Total Number 42
Disease Relevance 47.30
Pain Relevance 9.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
joints 5
synovium 5
leukocytes 4
apoptotic cells 4
plaques 2
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 1534 100.00 Very High Very High Very High
Inflammation 286 99.60 Very High Very High Very High
rheumatoid arthritis 416 99.24 Very High Very High Very High
ischemia 41 98.92 Very High Very High Very High
Chronic pancreatitis 26 96.36 Very High Very High Very High
Crohn's disease 26 95.28 Very High Very High Very High
fibrosis 26 94.52 High High
cytokine 58 90.00 High High
Pain 20 50.00 Quite Low
Neuropeptide 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 1554 100.00 Very High Very High Very High
Experimental Arthritis 1014 100.00 Very High Very High Very High
Cancer 578 100.00 Very High Very High Very High
Disease 510 99.88 Very High Very High Very High
Stress 44 99.84 Very High Very High Very High
INFLAMMATION 316 99.60 Very High Very High Very High
Arthritis 520 99.58 Very High Very High Very High
Rheumatoid Arthritis 416 99.24 Very High Very High Very High
Cv Unclassified Under Development 36 98.92 Very High Very High Very High
Autoimmune Thyroiditis 26 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of p53 protein on day 23 was confirmed by immunohistochemistry

in a separate experiment in six rats with AA.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53 associated with arthritis
1) Confidence 0.70 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.73 Pain Relevance 0.21
Overexpression of p53 was

observed in the intimal lining layer and synovial sublining in all rats on day 23.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53
2) Confidence 0.70 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.76 Pain Relevance 0.23
There is already some overexpression of p53 in the preclinical

phase and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with arthritis
3) Confidence 0.70 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.15 Pain Relevance 0.38
There is already some overexpression of p53 in the preclinical phase

and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with arthritis
4) Confidence 0.70 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.30 Pain Relevance 0.39
The

increased expression of p53 in the joints of rats with chronic AA was even greater than that observed in synovial tissue of RA patients with long-standing disease.

Positive_regulation (increased) of Gene_expression (expression) of p53 in joints associated with rheumatoid arthritis, disease and arthritis
5) Confidence 0.70 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.38 Pain Relevance 0.35
The important role of adenovirus-mediated wild type p53 gene transfer has been shown in several realms of tumor biology.
Positive_regulation (transfer) of Gene_expression (transfer) of p53 associated with cancer
6) Confidence 0.68 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.31 Pain Relevance 0
This

indicates that, although there was sufficient DNA damage to cause an increment in p53 expression in the early phases, DNA strand breaks that can be detected by TUNEL assays only occurred in chronic AA.

Positive_regulation (increment) of Gene_expression (expression) of p53 associated with arthritis
7) Confidence 0.50 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.97 Pain Relevance 0.31
AA is not the best model for p53 gene therapy,

however, because dramatic p53 overexpression occurs in the latter stages of the disease.



Neg (not) Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with disease and arthritis
8) Confidence 0.50 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.15 Pain Relevance 0.19
Taken together, significant apoptosis only occurs late in AA and it

follows marked p53 overexpression, making it is useful model for testing proapoptotic therapies.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with apoptosis and arthritis
9) Confidence 0.50 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.43 Pain Relevance 0.26
There is already some overexpression of p53 in the preclinical

phase and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Positive_regulation (increment) of Gene_expression (expression) of p53 associated with arthritis
10) Confidence 0.50 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.17 Pain Relevance 0.35
Factors other

than p53 may also play an important role in the actual induction of apoptosis, such as tumor necrosis factor-?

Positive_regulation (than) of Gene_expression (other) of p53 associated with necrosis, cancer and apoptosis
11) Confidence 0.50 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 2.03 Pain Relevance 0.44
There is already some overexpression of p53 in the preclinical phase

and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Positive_regulation (increment) of Gene_expression (expression) of p53 associated with arthritis
12) Confidence 0.50 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.12 Pain Relevance 0.36
Theoretically, this analysis allows determination of whether the transfection of wild-type p53 suppresses tumor cells before performing an in vivo experiment.
Spec (whether) Positive_regulation (transfection) of Spec (whether) Gene_expression (transfection) of p53 associated with cancer
13) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.17 Pain Relevance 0
Theoretically, this analysis allows determination of whether the transfection of wild-type p53 suppresses tumor cells before performing the in vivo experiment.
Spec (whether) Positive_regulation (transfection) of Spec (whether) Gene_expression (transfection) of p53 associated with cancer
14) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.79 Pain Relevance 0
The increased expression of p53

in the joints of rats with chronic AA was even greater than that observed in synovial tissue of RA patients with long-standing disease.

Positive_regulation (increased) of Gene_expression (expression) of p53 in joints associated with rheumatoid arthritis, disease and arthritis
15) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.86 Pain Relevance 0.56
Overexpression of p53 and increased numbers of apoptotic cells did

not occur simultaneously in this model; rather p53 overexpression preceded increased apoptosis.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53 in apoptotic cells associated with apoptosis
16) Confidence 0.47 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.52 Pain Relevance 0.36
Overexpression of p53 and increased numbers of apoptotic cells did not

occur simultaneously in this model; rather p53 overexpression preceded increased apoptosis.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53 in apoptotic cells associated with apoptosis
17) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.87 Pain Relevance 0.46
Overexpression of p53 was observed in the

intimal lining layer and synovial sublining in all rats on day 23 (Fig. 3).

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53
18) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.04 Pain Relevance 0.28
Expression of p53

in pooled rat AA joint extracts gradually increased from day 0 (6 arbitrary units) to day 23 (173 arbitrary units), which was markedly higher than p53 levels in RA synovium (32 arbitrary units; Table 1).

Positive_regulation (increased) of Gene_expression (Expression) of p53 in synovium associated with rheumatoid arthritis and arthritis
19) Confidence 0.47 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.75 Pain Relevance 0.17
There are also several examples of overexpression

of wild-type p53 in human inflammatory diseases, which include the following: inflammation in atherosclerotic plaques [32], idiopathic pulmonary fibrosis [33], Helicobacter pylori-associated gastritis [34,35], ulcerative colitis [36], Crohn's disease [36], chronic pancreatitis [37], infectious colitis [38], lymphocytic thyroiditis [39], and RA [1,24,40,41].

Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in plaques associated with colitis, crohn's disease, rheumatoid arthritis, pulmonary fibrosis, disease, fibrosis, inflammatory bowel disease, atherosclerotic plaque, inflammation, autoimmune thyroiditis, chronic pancreatitis and gastritis
20) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.82 Pain Relevance 0.59

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox