INT170

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Context Info
Confidence 0.55
First Reported 1977
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 52
Total Number 52
Disease Relevance 13.46
Pain Relevance 14.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
heart 3
synapses 2
plasma 1
sympathetic 1
nucleus 1
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 42 100.00 Very High Very High Very High
antidepressant 21 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
depression 5 99.86 Very High Very High Very High
Kappa opioid receptor 8 99.80 Very High Very High Very High
Clonidine 22 99.74 Very High Very High Very High
anesthesia 26 99.02 Very High Very High Very High
Catecholamine 3 98.92 Very High Very High Very High
beta blocker 63 98.88 Very High Very High Very High
Neurotransmitter 6 98.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 50 99.90 Very High Very High Very High
Depression 4 99.86 Very High Very High Very High
Hypertension 21 99.84 Very High Very High Very High
Stress 11 99.76 Very High Very High Very High
Nociception 9 99.76 Very High Very High Very High
Drug Eruptions 3 99.42 Very High Very High Very High
Heart Rate Under Development 90 99.12 Very High Very High Very High
Cv General 3 Under Development 28 98.64 Very High Very High Very High
Pain 3 96.92 Very High Very High Very High
Left Ventricular Dysfunction 3 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Before each stress test, intravenous metoprolol was given to achieve maximal or near maximal beta-adrenoceptor blockade.
Negative_regulation (blockade) of beta-adrenoceptor associated with stress
1) Confidence 0.55 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2240635 Disease Relevance 0.68 Pain Relevance 0.83
The lesser adverse impact of celiprolol on cardiac function may be attributable to ancillary cardiac stimulatory properties offsetting the cardiac depression after beta-adrenoceptor blockade.
Negative_regulation (blockade) of beta-adrenoceptor associated with depression
2) Confidence 0.55 Published 1986 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2935349 Disease Relevance 0.40 Pain Relevance 0.23
A single dose of 160 mg of long-acting propranolol can produce cardiac beta-adrenoceptor blockade throughout a 24 hr period without variability due to multiple peak concentrations.
Negative_regulation (blockade) of beta-adrenoceptor
3) Confidence 0.48 Published 1983 Journal Pharmacotherapy Section Abstract Doc Link 6361703 Disease Relevance 0.34 Pain Relevance 0.09
Carvedilol also possesses a peripheral vasodilating action mainly due to an alpha 1-adrenoceptor blockade.
Negative_regulation (blockade) of 1-adrenoceptor
4) Confidence 0.45 Published 1993 Journal Cardiology Section Abstract Doc Link 8106163 Disease Relevance 0.64 Pain Relevance 0.32
Beta-adrenoceptor blockade is effective in situations with increased sympathetic activity.
Negative_regulation (blockade) of Beta-adrenoceptor in sympathetic
5) Confidence 0.41 Published 1997 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9422300 Disease Relevance 0.10 Pain Relevance 0.18
Bisoprolol was associated with a 34% mortality benefit in CIBIS-II (Cardiac Insufficiency Bisoprolol Study II) and carvedilol was associated with a 35% mortality reduction in the COPERNICUS (Carvedilol Prospective Randomized Cumulative Survival) trial. beta-Adrenoceptor antagonists reduce perioperative mortality in patients undergoing cardiac as well as non-cardiac surgery; however, they remain underutilised.
Negative_regulation (reduce) of beta-Adrenoceptor associated with heart rate under development and antagonist
6) Confidence 0.41 Published 2005 Journal Drugs Section Abstract Doc Link 15819591 Disease Relevance 0.89 Pain Relevance 0.30
These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris.
Negative_regulation (blockade) of beta-adrenoceptor associated with angina
7) Confidence 0.41 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6156341 Disease Relevance 0.49 Pain Relevance 0.49
The degree of clinical beta-adrenoceptor blockade was quantified using the isoproterenol sensitivity test.
Negative_regulation (blockade) of beta-adrenoceptor
8) Confidence 0.39 Published 1990 Journal Anaesthesist Section Abstract Doc Link 1974748 Disease Relevance 0.25 Pain Relevance 0.50
The high systemic availability of pindolol after oral administration, due to good oral absorption and low first-pass effect, is revealed not only in pharmacokinetic studies but also in pharmacodynamic experiments; beta-adrenoceptor blockade 75 minutes after intravenous administration was equivalent to that observed 2 hours after the same doses given orally.
Negative_regulation (blockade) of beta-adrenoceptor
9) Confidence 0.39 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125094 Disease Relevance 0.09 Pain Relevance 0.03
Beta-adrenoceptor blockade is responsible for the therapeutic action of beta-adrenoceptor-blocking drugs in the treatment of hypertension and angina pectoris.
Negative_regulation (blockade) of Beta-adrenoceptor associated with angina and hypertension
10) Confidence 0.39 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125094 Disease Relevance 0.31 Pain Relevance 0.10
Both tracheal and right atrial beta-adrenoceptor blocking activity are markedly decreased by alkyl substitution in position 3 of parent catechol diether 1.
Negative_regulation (decreased) of beta-adrenoceptor
11) Confidence 0.36 Published 1977 Journal J. Med. Chem. Section Abstract Doc Link 15113 Disease Relevance 0 Pain Relevance 0.26
A linear correlation exists between the logarithm of plasma concentrations of pindolol and cardiac beta-adrenoceptor blockade expressed as a reduction of exercise-induced tachycardia.
Negative_regulation (blockade) of beta-adrenoceptor in plasma associated with heart rate under development
12) Confidence 0.34 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125094 Disease Relevance 0.15 Pain Relevance 0.03
Cardiac beta-adrenoceptor blockade can be measured in terms of the reduction of isoprenaline-induced and exercise-induced tachycardia.
Negative_regulation (blockade) of beta-adrenoceptor associated with heart rate under development
13) Confidence 0.34 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125094 Disease Relevance 0.36 Pain Relevance 0.12
Ketanserin is a 5-HT2 receptor antagonist without partial agonist properties which also possesses weak alpha 1-adrenoceptor antagonistic activity, which may explain its antihypertensive mechanism of action in patients with essential hypertension.
Negative_regulation (possesses) of 1-adrenoceptor associated with antagonist, hypertension and agonist
14) Confidence 0.33 Published 1990 Journal Drugs Section Abstract Doc Link 2079001 Disease Relevance 0.49 Pain Relevance 0.14
We report a case of (generalized) fixed drug eruption induced by atenolol, a beta adrenoreceptor blocking agent.
Negative_regulation (blocking) of adrenoreceptor associated with drug eruptions
15) Confidence 0.33 Published 1999 Journal J Med Assoc Thai Section Abstract Doc Link 10659553 Disease Relevance 0.54 Pain Relevance 0.09
John's wort (SJW) extract reduced beta-AR numbers in cultured cells to a similar extent as DMI or the selective serotonin re-uptake inhibitor fluoxetine.
Negative_regulation (numbers) of beta-AR associated with desipramine, serotonin and fluoxetine
16) Confidence 0.32 Published 2006 Journal Planta Med. Section Abstract Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.57
Acute inhibition of neurotransmitter reuptake in central neuronal synapses, followed by a down-regulation of central postsynaptic beta-adrenoceptor (beta-AR) numbers were consistently observed in vivo, while a reduction in surface beta-AR density was found in cell cultures.
Negative_regulation (regulation) of beta-AR in synapses associated with neurotransmitter
17) Confidence 0.32 Published 2006 Journal Planta Med. Section Abstract Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.46
Acute inhibition of neurotransmitter reuptake in central neuronal synapses, followed by a down-regulation of central postsynaptic beta-adrenoceptor (beta-AR) numbers were consistently observed in vivo, while a reduction in surface beta-AR density was found in cell cultures.
Negative_regulation (regulation) of beta-adrenoceptor in synapses associated with neurotransmitter
18) Confidence 0.32 Published 2006 Journal Planta Med. Section Abstract Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.46
Vitamin E reduces antidepressant-related beta-adrenoceptor down-regulation in cultured cells.
Negative_regulation (reduces) of beta-adrenoceptor associated with antidepressant
19) Confidence 0.32 Published 2006 Journal Planta Med. Section Title Doc Link 17109256 Disease Relevance 0 Pain Relevance 0.51
Oxprenolol and propranolol are noncardioselective beta adrenoreceptor blocking agents known to be equally effective in the management of patients with angina pectoris.
Negative_regulation (effective) of adrenoreceptor associated with angina
20) Confidence 0.32 Published 1981 Journal Am. J. Cardiol. Section Abstract Doc Link 7223659 Disease Relevance 0.25 Pain Relevance 0.25

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