INT170027

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2000
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.12
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee joint 1
knee 1
Kcnmb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 424 100.00 Very High Very High Very High
substance P 420 100.00 Very High Very High Very High
Arthritis 384 99.68 Very High Very High Very High
Pain 132 99.04 Very High Very High Very High
Inflammation 288 98.00 Very High Very High Very High
agonist 88 92.64 High High
dorsal root ganglion 216 75.04 Quite High
Root ganglion neuron 4 75.00 Quite High
Hyperalgesia 64 54.16 Quite High
b2 receptor 16 49.60 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 432 99.68 Very High Very High Very High
Pain 124 99.04 Very High Very High Very High
INFLAMMATION 272 98.00 Very High Very High Very High
Immunization 16 95.80 Very High Very High Very High
Dislocations 4 87.08 High High
Nociception 72 80.52 Quite High
Ganglion Cysts 220 75.04 Quite High
Bordatella Infection 12 61.04 Quite High
Sprains And Strains 4 56.04 Quite High
Mycobacterial Infection 4 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that in AIA in the rat the expression of SP-binding and BK-binding sites in the perikarya of DRGs L1–L5 is markedly upregulated in the course of knee inflammation.
Gene_expression (expression) of BK-binding in knee associated with inflammation, bradykinin, substance p and arthritis
1) Confidence 0.01 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.11 Pain Relevance 1.22
These results show that the expression of SP-binding and BK-binding sites in the perikarya of DRGs L1–L5 is markedly upregulated in the course of inflammation in the knee joint.
Gene_expression (expression) of BK-binding in knee joint associated with inflammation, bradykinin and substance p
2) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.73 Pain Relevance 0.96
In the first series (n = 31 rats), we determined the expression of SP-binding and BK-binding sites in the DRGs of lumbar segments L1–L5.
Spec (determined) Gene_expression (expression) of BK-binding associated with bradykinin and substance p
3) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.78 Pain Relevance 0.29
Because the increased expression of BK-binding sites persisted for up to 42 days on the side of inflammation, BK-binding sites should be an interesting target for pain treatment in the acute and chronic phases of arthritis.
Gene_expression (expression) of BK-binding associated with pain, inflammation, bradykinin and arthritis
4) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.48 Pain Relevance 1.48

General Comments

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