INT170029

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.79
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 2
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 465 100.00 Very High Very High Very High
bradykinin 212 100.00 Very High Very High Very High
cytokine 30 99.08 Very High Very High Very High
b2 receptor 8 98.92 Very High Very High Very High
agonist 44 88.04 High High
Hyperalgesia 32 83.12 Quite High
Inflammation 168 81.00 Quite High
Pain 66 77.60 Quite High
dorsal root ganglion 108 75.04 Quite High
substance P 210 55.44 Quite High
Disease Link Frequency Relevance Heat
Arthritis 502 100.00 Very High Very High Very High
Hyperalgesia 32 83.12 Quite High
INFLAMMATION 160 81.00 Quite High
Pain 62 77.60 Quite High
Ganglion Cysts 110 75.04 Quite High
Pressure And Volume Under Development 23 61.16 Quite High
Disease Progression 2 60.60 Quite High
Disease 49 55.68 Quite High
Body Weight 6 53.24 Quite High
Nociception 36 42.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore conclude that the increased expression of BK receptors in AIA is entirely due to an upregulation of the B2 receptor.


Positive_regulation (increased) of Gene_expression (expression) of AIA associated with b2 receptor, bradykinin and arthritis
1) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.99 Pain Relevance 1.30
We therefore conclude that the increased expression of BK receptors in AIA is entirely due to an upregulation of the B2 receptor.


Positive_regulation (due) of Gene_expression (expression) of AIA associated with b2 receptor, bradykinin and arthritis
2) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.99 Pain Relevance 1.28
The degree of BMD reduction is dictated by the extent of leukocyte infiltration as osteoclast recruitment along bony surfaces is induced by numerous proinflammatory cytokines [155]; accordingly, bone dissolution is more severe in AIA (Figure 4), where leukocyte influx is more severe than in CIA or SCW.
Positive_regulation (severe) of Gene_expression (severe) of AIA in leukocyte associated with arthritis and cytokine
3) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 0.81 Pain Relevance 0.31

General Comments

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