INT170033

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 7
Speculated 1
Reported most in Body
Documents 59
Total Number 60
Disease Relevance 20.99
Pain Relevance 16.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
neurons 10
dorsal horn 5
bar 4
fibroblast 2
nucleus 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 387 100.00 Very High Very High Very High
Glutamate 282 100.00 Very High Very High Very High
Spinal cord 194 100.00 Very High Very High Very High
Spinal nerve ligature 182 100.00 Very High Very High Very High
Dopamine 118 100.00 Very High Very High Very High
dorsal root ganglion 118 100.00 Very High Very High Very High
substance P 114 100.00 Very High Very High Very High
amygdala 85 100.00 Very High Very High Very High
Dorsal horn 84 100.00 Very High Very High Very High
tetrodotoxin 74 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 254 100.00 Very High Very High Very High
Hypersensitivity 135 100.00 Very High Very High Very High
Osteoporosis 45 100.00 Very High Very High Very High
Sprains And Strains 36 100.00 Very High Very High Very High
Hypoxia 7 100.00 Very High Very High Very High
Arthritis 112 99.76 Very High Very High Very High
Apoptosis 210 99.62 Very High Very High Very High
Increased Venous Pressure Under Development 33 99.60 Very High Very High Very High
Aging 36 99.10 Very High Very High Very High
Death 200 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sessions 2–5 in which the rats received noncontingent amphetamine, the visual signal group markedly increased lever pressing (Fig. 2A; a significant main concentration effect, F2,6?
Positive_regulation (increased) of Gene_expression (pressing) of Fig in lever
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806927 Disease Relevance 0 Pain Relevance 0
An interesting observation in the present study was the delayed recovery of base deficit after resuscitation (Table 1), whereas PeCO2, PaCO2, and the gap between them were actually recovered (Fig. 1).
Positive_regulation (recovered) of Gene_expression (recovered) of Fig
2) Confidence 0.42 Published 2003 Journal Crit Care Section Body Doc Link PMC154116 Disease Relevance 0.28 Pain Relevance 0
Consistent with these observations, our rat model of hemorrhage/resuscitation led to increased hepatic formation of both ROS and RNS, as evidenced by hepatic 4-HNE adduct formation (Fig. 4), protein nitration (Fig. 5) and increased iNOS expression (Fig 6).
Positive_regulation (increased) of Gene_expression (expression) of Fig 6 associated with cva
3) Confidence 0.38 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2936410 Disease Relevance 0.68 Pain Relevance 0.24
Jones et al. previously reported that intracranial pressure in hydrocephalic H-Tx rats increases around 10d of age [32,65,66], this correlates with the overall increase in GFAP expression (Fig. 9) and the amount of GFAP stained cells that were seen in the hydrocephalic animals in this study.
Positive_regulation (increase) of Gene_expression (expression) of Fig associated with cva
4) Confidence 0.36 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.78 Pain Relevance 0.05
After rinsing, intercellular transfer Lucifer yellow dye initially improved before declining again (Fig. 6, ANOVA, p ?
Positive_regulation (improved) of Gene_expression (improved) of Fig
5) Confidence 0.34 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC222921 Disease Relevance 0 Pain Relevance 0
The numbers of cells in the clusters decreased over time, whereas type II collagen and GAG production increased (Fig. 3).
Positive_regulation (increased) of Gene_expression (production) of Fig
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
Application of ACSF2 also resulted in similar trends in the average variance of the membrane potential to those in Fig. 2 (Fig. 4B, n?
Positive_regulation (variance) of Gene_expression (those) of Fig
7) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075161 Disease Relevance 0 Pain Relevance 0
Application of ACSF2 also resulted in similar trends in the average variance of the membrane potential to those in Fig. 2 (Fig. 4B, n?
Positive_regulation (variance) of Gene_expression (those) of Fig
8) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075161 Disease Relevance 0 Pain Relevance 0
The effect of cement composition on interface longevity was studied using prism-shaped anchors with differing molarities of OA (Fig. 4a), increasing P:Ls (Fig. 4b) and the addition of citric acid to OA prior to combination with the ?
Positive_regulation (differing) of Gene_expression (molarities) of Fig associated with aging
9) Confidence 0.29 Published 2010 Journal Ann Biomed Eng Section Body Doc Link PMC2871103 Disease Relevance 0.34 Pain Relevance 0
The MAPK signaling pathway was markedly up regulated, and this was reflected by the 1.9-fold increase in the expression of Map3k3.Fig. 6KEGG function pathways affected at 12 h post bolus when rats fed betaine were compared to rats fed dextrose (n = 3, the number of genes on each pathway is listed on the x axis)
Positive_regulation (increase) of Gene_expression (expression) of Fig
10) Confidence 0.26 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.13 Pain Relevance 0.06
A relatively rapid inhibition of M/KCNQ currents was observed immediately after NGF application on both types of neurons, with average inhibition of 25 ± 2% for phasic (phasic 1 and phasic 2) and 26 ± 3% for tonic neurons (n = 10 and 6, respectively) (Fig. 3, A and B).
Positive_regulation (immediately) of Spec (observed) Gene_expression (application) of Fig in neurons associated with nerve growth factor
11) Confidence 0.26 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.17 Pain Relevance 0.42
M) in the presence of NGF (Fig. 6, C and D; n = 5, P < 0.01); Oxo-M increased the number of spikes fired in phasic neurons from 4.4 ± 0.7 to 22 ± 5 in the presence of NGF (Fig. 6 D).
Positive_regulation (increased) of Gene_expression (presence) of Fig in neurons associated with nerve growth factor
12) Confidence 0.26 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.13 Pain Relevance 0.58
M) in the presence of NGF (Fig. 6, C and D; n = 5, P < 0.01); Oxo-M increased the number of spikes fired in phasic neurons from 4.4 ± 0.7 to 22 ± 5 in the presence of NGF (Fig. 6 D).
Positive_regulation (increased) of Gene_expression (presence) of Fig in neurons associated with nerve growth factor
13) Confidence 0.26 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.13 Pain Relevance 0.58
Cumulative analysis of sEPSC amplitude (Fig. 5B) confirmed that the amplitude distribution of sEPSCs in pyramidal neurons from stressed rats was significantly different from all the other experimental groups (D?
Positive_regulation (Cumulative) of Gene_expression (analysis) of Fig in pyramidal neurons associated with pyramidal cell
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.44 Pain Relevance 0.27
Corticosterone levels were measured 2 h following the last dose.Fig. 6Multi-day side effects study (N = 10 for each group, presented with error bar as standard deviation) Corticosterone level (2 h post the last dose)
Positive_regulation (following) of Gene_expression (measured) of Fig in bar
15) Confidence 0.24 Published 2010 Journal Nanoscale Res Lett Section Body Doc Link PMC2893943 Disease Relevance 0.13 Pain Relevance 0.10
There was also an increase in CD11b immunostaining after tendon ligation (Fig. 6a, CD11b: TL-3 d and 2w).


Positive_regulation (increase) of Gene_expression (immunostaining) of Fig in tendon
16) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.70 Pain Relevance 0.94
In contrast, progesterone treatment did not exert effects on the E-selectin expression of lung of OVX-allergic rats (Fig. 10A).
Neg (not) Positive_regulation (exert) of Gene_expression (expression) of Fig in lung associated with hypersensitivity
17) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.06 Pain Relevance 0
The 0.1 ng dose only produced a significant increase in EF50 on the contralateral side (p < 0.05) (Fig. 3B), although there was a trend to produce an increase in EF50 on the ipsilateral side (Fig. 3A).
Positive_regulation (increase) of Gene_expression (produce) of Fig
18) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.93 Pain Relevance 0.86
The L5 nerve transsection produced an upregulation in all SC segments for CATS as well as CATX (Fig. 4A).
Positive_regulation (upregulation) of Gene_expression (produced) of Fig in nerve
19) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.14 Pain Relevance 0.13
The effects of Laf were abolished by prior de-afferentation as a result of high-dose capsaicin pretreatment (Cap-t) (Fig. 3a, b), suggesting that Laf-induced hyperemia is mediated by the activation of CSAN.Fig1Effect of luminal capsaicin (Cap) on interstitial pH (pHint) and blood flow in rat esophagus. pHint (a) and blood flow (b) were monitored during the luminal perfusion of Cap (30 and 100 ?
Positive_regulation (activation) of Gene_expression (1Effect) of Fig in blood associated with qutenza and increased venous pressure under development
20) Confidence 0.19 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.19 Pain Relevance 0.97

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