INT170053

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.34
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
knee joints 1
lung 1
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 87 99.76 Very High Very High Very High
interstitial cystitis 82 99.32 Very High Very High Very High
rheumatoid arthritis 112 98.20 Very High Very High Very High
cytokine 117 92.12 High High
Inflammation 144 90.44 High High
Inflammatory response 20 79.56 Quite High
Lasting pain 2 73.36 Quite High
Arthritis 35 70.48 Quite High
cva 2 65.48 Quite High
pain pelvic 2 40.40 Quite Low
Disease Link Frequency Relevance Heat
Cystitis 140 99.88 Very High Very High Very High
Disease 113 99.36 Very High Very High Very High
Interstitial Cystitis 82 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 65 98.56 Very High Very High Very High
Rheumatoid Arthritis 113 98.20 Very High Very High Very High
Granuloma 5 97.40 Very High Very High Very High
Mycobacterial Infection 145 97.20 Very High Very High Very High
Infection 117 94.64 High High
Adhesions 10 93.12 High High
INFLAMMATION 157 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, CXCL9, CXCL10, and CXCL11 bind to a common receptor, CXCR3.
CXCL9 Binding (bind) of
1) Confidence 0.46 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.68 Pain Relevance 0.61
Perhaps in association with the differences between the various forms of IC and murine CYP-induced cystitis, CXCL10 (followed by CXCL9) was higher in mice with CYP-induced cystitis, but CXCL9 (followed by CXCL10) was found to be higher in IC patients.
CXCL9 Binding (found) of associated with cystitis and interstitial cystitis
2) Confidence 0.31 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.50 Pain Relevance 0.93
, IL-6, IP-10, and Mig, and coincided with those of TNF-?
Mig Binding (coincided) of
3) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.27 Pain Relevance 0.23
The CXC chemokines CXCL10 and CXCL9 were undetectable in control patients and expressed equally in CU and CI knee joints.
CXCL9 Binding (undetectable) of in knee joints associated with chemokine
4) Confidence 0.24 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.93 Pain Relevance 0.59
Some of the differentially expressed proteins, for example, MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11), might indeed serve as markers for disease activity in SLE, because these were differentially expressed between active and inactive disease, and not only between SLE patients and controls.
CXCL9 Spec (might) Binding (serve) of associated with systemic lupus erythematosus and disease
5) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.08 Pain Relevance 0.05
The receptor for CXCL9, CXCR3 is expressed on activated T cells that are recruited to the M.tuberculosis infected lung [74].
CXCL9 Binding (receptor) of in lung associated with mycobacterial infection
6) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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