INT170056

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 12.72
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
macrophage 1
knee joints 1
lung 1
mast cells 1
synovial joints 1
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
interstitial cystitis 164 100.00 Very High Very High Very High
chemokine 175 99.98 Very High Very High Very High
rheumatoid arthritis 126 98.64 Very High Very High Very High
Inflammation 286 97.44 Very High Very High Very High
cytokine 261 95.72 Very High Very High Very High
cINOD 32 92.68 High High
Inflammatory response 36 79.60 Quite High
Inflammatory mediators 12 78.12 Quite High
fibrosis 15 75.72 Quite High
Lasting pain 4 73.36 Quite High
Disease Link Frequency Relevance Heat
Cystitis 280 100.00 Very High Very High Very High
Interstitial Cystitis 164 100.00 Very High Very High Very High
Disease 178 99.36 Very High Very High Very High
Rheumatoid Arthritis 127 98.64 Very High Very High Very High
Systemic Lupus Erythematosus 68 98.56 Very High Very High Very High
Targeted Disruption 40 98.44 Very High Very High Very High
INFLAMMATION 322 97.44 Very High Very High Very High
Lymphedema 45 96.88 Very High Very High Very High
Infection 109 96.44 Very High Very High Very High
Adhesions 18 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, CXCL9, CXCL10, and CXCL11 bind to a common receptor, CXCR3.
CXCL10 Binding (bind) of
1) Confidence 0.45 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.68 Pain Relevance 0.60
Perhaps in association with the differences between the various forms of IC and murine CYP-induced cystitis, CXCL10 (followed by CXCL9) was higher in mice with CYP-induced cystitis, but CXCL9 (followed by CXCL10) was found to be higher in IC patients.
CXCL10 Binding (found) of associated with cystitis and interstitial cystitis
2) Confidence 0.35 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.49 Pain Relevance 0.92
Taken together, the present study presents a scenario where CYP induction leads to increased numbers of both systemic and mucosal mast cells, partially through CXCL10-CXCR3 interactions.
CXCL10 Binding (interactions) of in mast cells
3) Confidence 0.34 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.94 Pain Relevance 0.46
Perhaps in association with the differences between the various forms of IC and murine CYP-induced cystitis, CXCL10 (followed by CXCL9) was higher in mice with CYP-induced cystitis, but CXCL9 (followed by CXCL10) was found to be higher in IC patients.
CXCL10 Binding (association) of associated with cystitis and interstitial cystitis
4) Confidence 0.29 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.61 Pain Relevance 1.00
, IL-6, IP-10, and Mig, and coincided with those of TNF-?
IP-10 Binding (coincided) of
5) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.27 Pain Relevance 0.24
and CXCL-10 have been highly associated with rejection in human cardiac and lung allograft recipients [32]–[34] and the appearance of IFN-?
CXCL-10 Spec (appearance) Binding (associated) of in lung
6) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.52 Pain Relevance 0.16
 ; granulocyte and granulocyte-macrophage colony-stimulating factors; IP10; and VEGF-A) showed no significant differences between treated and untreated lymphedema cohorts.


IP10 Binding (granulocyte) of in macrophage associated with lymphedema
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 1.12 Pain Relevance 0.82
as well as chemokine (C-X-C motif) ligands IP-10 (Cxcl10), KC (Cxcl1), and MCP-1 (Ccl2).
Cxcl10 Binding (ligands) of associated with chemokine
8) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.42 Pain Relevance 0.14
as well as chemokine (C-X-C motif) ligands IP-10 (Cxcl10), KC (Cxcl1), and MCP-1 (Ccl2).
IP-10 Binding (ligands) of associated with chemokine
9) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.41 Pain Relevance 0.14
The CXC chemokines CXCL10 and CXCL9 were undetectable in control patients and expressed equally in CU and CI knee joints.
CXCL10 Binding (undetectable) of in knee joints associated with chemokine
10) Confidence 0.20 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.93 Pain Relevance 0.59
Migration of PBLs could be further enhanced by the addition of CXCL-10, CCL5, or CXCL-12 to the lower chamber, chemokines known to be up-regulated in RA synovial joints (Figure 6C).29 Subset analysis revealed enhanced migration of TCR?
CXCL-10 Binding (addition) of in synovial joints associated with chemokine and rheumatoid arthritis
11) Confidence 0.19 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.16
and CXCL-10 inserted via sticky end ligation using standard methods.
CXCL-10 Binding (ligation) of
12) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0
Some of the differentially expressed proteins, for example, MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11), might indeed serve as markers for disease activity in SLE, because these were differentially expressed between active and inactive disease, and not only between SLE patients and controls.
IP-10 Spec (might) Binding (serve) of associated with systemic lupus erythematosus and disease
13) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.08 Pain Relevance 0.05
Deconvolution of the positive pools revealed a cDNA clone that was able to mediate cross-linking to both CCL5 and CCL11 (Fig. 2 a, lanes 4 and 5), but not CXCL10 when tested in HEK293 cells.
CXCL10 Binding (linking) of
14) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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