INT1701

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.36
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) cytoplasmic membrane-bounded vesicle (Neu1) plasma membrane (Neu1)
molecular_function (Neu1) cellular_component (Neu1) biological_process (Neu1)
Anatomy Link Frequency
neutrophils 3
macrophages 1
leukocyte 1
peritoneal macrophages 1
urine 1
Neu1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 99.28 Very High Very High Very High
Inflammatory mediators 2 98.56 Very High Very High Very High
cINOD 2 96.80 Very High Very High Very High
Analgesic 14 96.72 Very High Very High Very High
aspirin 7 96.52 Very High Very High Very High
Inflammation 33 96.44 Very High Very High Very High
Clonidine 2 95.66 Very High Very High Very High
Arthritis 2 93.40 High High
dexamethasone 1 93.16 High High
Pain 7 92.16 High High
Disease Link Frequency Relevance Heat
Pleurisy 1 99.36 Very High Very High Very High
Granuloma 1 98.86 Very High Very High Very High
INFLAMMATION 38 98.56 Very High Very High Very High
Pressure And Volume Under Development 18 98.40 Very High Very High Very High
Edema 1 98.08 Very High Very High Very High
Autoimmune Disease 1 95.64 Very High Very High Very High
Pancreatitis 4 94.32 High High
Experimental Arthritis 2 93.40 High High
Pain 4 92.16 High High
Hypersensitivity 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of these experiments suggesting that the resting cell population of the pleural space contributed to the response, and that lysosomal enzyme release may play only a minor role in the mediation of increased vascular permeability.
Localization (release) of lysosomal enzyme associated with edema
1) Confidence 0.69 Published 1979 Journal J. Rheumatol. Section Abstract Doc Link 226701 Disease Relevance 0.51 Pain Relevance 0.26
Hyperamylasaemia, pancreatic oedema and activation of trypsinogen in the pancreatic tissue, as well as subcellular redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction, were prevented by infusion of 20 mg/kg.h cetraxate for 2 h before caerulein infusion and throughout the 3.5 h of caerulein infusion (5 micrograms/kg.h).
Localization (redistribution) of lysosomal enzyme associated with pressure and volume under development
2) Confidence 0.43 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.51 Pain Relevance 0.06
Moreover, the extracts suppressed the release of beta-glucuronidase, a lysosomal enzyme in rat neutrophils.
Localization (release) of lysosomal enzyme in neutrophils
3) Confidence 0.41 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875511 Disease Relevance 0.26 Pain Relevance 0.17
All of them, except clonidine, and in contrast to NSAI drugs, were more potent on PAF-acether edema than on kaolin edema; a possible link between these agents is their ability to increase cyclic AMP levels in the cells and consequently to reduce lysosomal enzyme release.
Localization (release) of lysosomal enzyme associated with pressure and volume under development, inflammation and clonidine
4) Confidence 0.12 Published 1981 Journal Agents Actions Section Abstract Doc Link 7340441 Disease Relevance 1.85 Pain Relevance 1.13
Inhibitory effects of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl- 2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate (AA-2379) on lysosomal enzyme and arachidonic acid release from rat polymorphonuclear leukocytes and its mode of action.
Localization (release) of lysosomal enzyme in polymorphonuclear leukocytes
5) Confidence 0.06 Published 1989 Journal Agents Actions Section Title Doc Link 2556899 Disease Relevance 0.26 Pain Relevance 0.09
These results suggest that AP has a potent anti-inflammatory and analgesic activity in sodium urate crystal-induced inflammations, and these effects are exerted through its combined inhibitions of PGE2 synthesis, leukocyte chemotaxis and lysosomal enzyme release.
Localization (release) of lysosomal enzyme in leukocyte associated with inflammation and analgesic
6) Confidence 0.05 Published 1991 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1783328 Disease Relevance 0.36 Pain Relevance 0.31
Measurements were made before, during and after drug intake, of epithelial cells and lysosomal enzyme (beta-d-n-acetyl glucosaminidase) excretion in urine.
Localization (excretion) of lysosomal enzyme in urine
7) Confidence 0.04 Published 1978 Journal Curr Med Res Opin Section Abstract Doc Link 699625 Disease Relevance 0.25 Pain Relevance 0.21
In in vitro experiments, auranofin did not show any suppression of cyclooxygenase activity, but was capable of suppression of lysosomal enzyme release and chemotaxis of neutrophils and macrophages.
Localization (release) of lysosomal enzyme in macrophages
8) Confidence 0.03 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3937805 Disease Relevance 0.74 Pain Relevance 0.52
Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages.
Localization (secretion) of lysosomal enzyme in peritoneal macrophages associated with qutenza
9) Confidence 0.03 Published 1997 Journal Lipids Section Title Doc Link 9397403 Disease Relevance 0.34 Pain Relevance 0.72
In rats the oral administration of CS significantly decreases granuloma formation due to sponge implants and cell migration and lysosomal enzyme release in carrageenan pleurisy.
Localization (release) of lysosomal enzyme associated with pleurisy and granuloma
10) Confidence 0.03 Published 1998 Journal Osteoarthr. Cartil. Section Abstract Doc Link 9743814 Disease Relevance 0.54 Pain Relevance 0.18
In in vitro experiments, auranofin did not show any suppression of cyclooxygenase activity, but was capable of suppression of lysosomal enzyme release and chemotaxis of neutrophils and macrophages.
Localization (release) of lysosomal enzyme in neutrophils
11) Confidence 0.01 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3937805 Disease Relevance 0.74 Pain Relevance 0.52

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