INT17018

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AHSP) protein folding (AHSP) cytoplasm (AHSP)
Anatomy Link Frequency
endothelial cells 4
vessels 2
AHSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 96.72 Very High Very High Very High
agonist 1 89.00 High High
Angina 2 82.96 Quite High
Serotonin 3 82.24 Quite High
5HT 1 81.36 Quite High
Dismenorea 1 53.84 Quite High
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 7 92.44 High High
Stress 1 87.24 High High
Cv General 3 Under Development 2 82.96 Quite High
Coronary Vasospasm 3 82.12 Quite High
Hypoxia 4 61.60 Quite High
Dysmenorrhea 1 53.84 Quite High
Premature Birth 1 46.96 Quite Low
Adhesions 1 46.56 Quite Low
Spontaneous Abortion 2 46.20 Quite Low
Hypertension 4 43.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In porcine coronary vessels the amount of EDRF released can be increased by a diet of codliver oil and decreased by a high cholesterol diet.
Positive_regulation (increased) of Localization (released) of EDRF in vessels
1) Confidence 0.70 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2038073 Disease Relevance 0.54 Pain Relevance 0.25
EDRF is a potent, endogenous vasodilator that is produced and released from endothelial cells and subsequently causes the relaxation of VSM through the activation of soluble guanylate cyclase and an increase in VSM cyclic GMP.
Positive_regulation (causes) of Localization (released) of EDRF in endothelial cells
2) Confidence 0.50 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0 Pain Relevance 0
Acetylcholine stimulates muscarinic receptors of endothelial cells resulting in the release of endothelium-derived relaxing factor (EDRF), and possibly nitric oxide.
Spec (possibly) Positive_regulation (resulting) of Localization (release) of EDRF in endothelial cells
3) Confidence 0.43 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0.05 Pain Relevance 0.41

General Comments

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