INT170182

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.47
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT2A1) small molecule metabolic process (SULT2A1) cytoplasm (SULT2A1)
Anatomy Link Frequency
molar 4
SULT2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 170 99.36 Very High Very High Very High
Arthritis 225 99.24 Very High Very High Very High
Inflammation 60 98.88 Very High Very High Very High
spinal inflammation 15 98.48 Very High Very High Very High
depression 48 97.60 Very High Very High Very High
cINOD 70 95.48 Very High Very High Very High
cytokine 5 81.76 Quite High
dexamethasone 5 58.84 Quite High
Rheumatism 5 47.84 Quite Low
iatrogenic 3 30.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 220 99.36 Very High Very High Very High
Arthritis 215 99.24 Very High Very High Very High
Seronegative Spondarthritis 35 99.20 Very High Very High Very High
Chronic Fatigue Syndrome 416 98.44 Very High Very High Very High
Fatigue 64 98.12 Very High Very High Very High
Depression 48 97.60 Very High Very High Very High
Insulin Resistance 42 97.56 Very High Very High Very High
Anxiety Disorder 41 97.04 Very High Very High Very High
Disease 147 94.32 High High
Stress 89 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concentration of DHEAS in both serum and synovial tissue is decreased in established RA [9].
Negative_regulation (decreased) of DHEAS associated with rheumatoid arthritis
1) Confidence 0.34 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30711 Disease Relevance 1.18 Pain Relevance 0.61
DHEAS concentrations were significantly decreased in both women and men with inflammatory arthritis (IA) (P < 0.001).
Negative_regulation (decreased) of DHEAS associated with inflammation and arthritis
2) Confidence 0.34 Published 2001 Journal Arthritis Res Section Abstract Doc Link PMC30711 Disease Relevance 1.20 Pain Relevance 0.60
The third is that normalization of high DHEAS levels in responders may be secondary to improvement in some clinical features such as sleep disturbances, anxiety or some depression symptoms which may be available in these patients.45 Indeed, the finding of the present study of a positive correlation between reduction of the DHEAS levels with galantamine treatment and recovery in clinical depression and anxiety scales in only respondent patients supports this hypothesis strongly.
Negative_regulation (reduction) of DHEAS associated with depression and anxiety disorder
3) Confidence 0.28 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.61 Pain Relevance 0.10
After the treatment DHEAS levels (mean±SD: 1114.77±638.60) were significantly decreased compared to those before the treatment (mean±SD: 1536.37±1094.72)(F=6.723, p=0.018).
Negative_regulation (decreased) of DHEAS
4) Confidence 0.28 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.09 Pain Relevance 0
Finally, the cholinergic effect of galantamine that facilitates release of CRH may cause reduction in DHEAS levels and the normalization of high DHEAS/cortisol molar ratio.
Negative_regulation (reduction) of DHEAS in molar
5) Confidence 0.28 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.51 Pain Relevance 0.08
It is possible to explain the high pre-treatment basal DHEAS levels and DHEAS/cortisol molar ratio in responders and the decrease in DHEAS levels with galantamine hydrobromide treatment in all CFS patients and especially in responders in several ways.
Negative_regulation (decrease) of DHEAS in molar associated with chronic fatigue syndrome
6) Confidence 0.28 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.30 Pain Relevance 0
They found significant reductions in DHEAS after hydrocortisone treatment.
Negative_regulation (reductions) of DHEAS
7) Confidence 0.28 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.74 Pain Relevance 0
In the present study, we found decreased DHEAS concentrations in both women and men with RA, Spa, or UIA.
Negative_regulation (decreased) of DHEAS associated with rheumatoid arthritis and arthritis
8) Confidence 0.25 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30711 Disease Relevance 1.30 Pain Relevance 0.58
In the present study, we compared serum DHEAS concentrations in 87 patients who had IA (RA, spondyloarthropathy [Spa], or undifferentiated inflammatory arthritis [UIA]) with the concentrations in controls matched for age and sex, and investigated whether decreased serum DHEAS concentrations in IA could be accounted for by the acute-phase response, previous glucocorticoid usage, current NSAID treatment, duration of disease, and insulin resistance.


Negative_regulation (decreased) of DHEAS associated with inflammation, cinod, rheumatoid arthritis, insulin resistance, disease and arthritis
9) Confidence 0.25 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30711 Disease Relevance 1.91 Pain Relevance 0.88
Both elevated and decreased DHEAS concentrations have been reported in ankylosing spondylitis [19,20].
Negative_regulation (decreased) of DHEAS associated with spinal inflammation
10) Confidence 0.25 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30711 Disease Relevance 1.25 Pain Relevance 0.69
In conclusion, decreases in basal DHEAS levels and DHEAS/cortisol molar ratios in CFS patients with galantamine treatment may somewhat support the hypothesis that cholinergic deficit may be present in CFS.
Negative_regulation (decreases) of DHEAS in molar associated with chronic fatigue syndrome
11) Confidence 0.21 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.60 Pain Relevance 0.06
The findings of the decrease in basal DHEAS levels and DHEAS/cortisol molar ratios normalizing with galantamine treatment may give some support to the cholinergic deficit hypothesis in CFS.



Negative_regulation (decrease) of DHEAS in molar associated with chronic fatigue syndrome
12) Confidence 0.21 Published 2009 Journal Psychiatry Investigation Section Abstract Doc Link PMC2796068 Disease Relevance 0.44 Pain Relevance 0
Similarly, we also found decreased DHEAS levels after galantamine treatment in CFS patients.
Negative_regulation (decreased) of DHEAS associated with chronic fatigue syndrome
13) Confidence 0.21 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.74 Pain Relevance 0
Laboratory goals include normalization of androstenedione and testosterone levels; alternatively, suppression of DHEAS levels occurs with minimal doses of glucocorticoids.
Negative_regulation (suppression) of DHEAS
14) Confidence 0.13 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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