INT17020

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Context Info
Confidence 0.80
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.82
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AHSP) protein folding (AHSP) cytoplasm (AHSP)
Anatomy Link Frequency
endothelial cells 2
endothelium 2
vein 2
smooth muscle 1
vessels 1
AHSP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 14 99.96 Very High Very High Very High
Clonidine 14 98.66 Very High Very High Very High
Nicotine 18 98.56 Very High Very High Very High
substance P 12 98.44 Very High Very High Very High
Calcitonin gene-related peptide 8 96.84 Very High Very High Very High
Angina 9 93.88 High High
antagonist 3 88.64 High High
Somatostatin 3 85.84 High High
Serotonin 6 80.88 Quite High
qutenza 5 80.48 Quite High
Disease Link Frequency Relevance Heat
Hyperlipidemia 2 99.52 Very High Very High Very High
Increased Venous Pressure Under Development 68 99.32 Very High Very High Very High
Stress 2 99.08 Very High Very High Very High
Atherosclerosis 4 99.02 Very High Very High Very High
Hypertension 5 98.68 Very High Very High Very High
Spasticity 8 97.52 Very High Very High Very High
Cv General 3 Under Development 4 93.88 High High
Coronary Vasospasm 5 93.04 High High
Myocardial Infarction 2 89.52 High High
Hypertrophy 1 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In porcine coronary vessels the amount of EDRF released can be increased by a diet of codliver oil and decreased by a high cholesterol diet.
Localization (released) of EDRF in vessels
1) Confidence 0.80 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2038073 Disease Relevance 0.54 Pain Relevance 0.24
In conclusion, we found no evidence for endothelial alpha 2-adrenoceptor-mediated release of EDRF in human hand veins.
Localization (release) of EDRF in veins
2) Confidence 0.78 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8095374 Disease Relevance 0 Pain Relevance 0.77
To investigate whether clonidine's modest constrictor effect in human veins is due to simultaneous release of EDRF, the dorsal hand vein compliance technique was used to measure vascular responses in healthy volunteers.
Localization (release) of EDRF in vein associated with clonidine
3) Confidence 0.78 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8095374 Disease Relevance 0 Pain Relevance 0.65
EDRF is a potent, endogenous vasodilator that is produced and released from endothelial cells and subsequently causes the relaxation of VSM through the activation of soluble guanylate cyclase and an increase in VSM cyclic GMP.
Localization (released) of EDRF in endothelial cells
4) Confidence 0.75 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0 Pain Relevance 0
Therefore, nicotine prevents or abolishes the vasoconstrictive effects of PGE2 through the release of EDRF.
Localization (release) of EDRF in PGE2 associated with nicotine
5) Confidence 0.75 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0 Pain Relevance 0.34
According to present knowledge, altered arterial reactivity associated with hypertension, atherosclerosis and hypercholesterolemia is related to impaired release of endothelial derived relaxing factor (EDRF).
Localization (release) of EDRF associated with atherosclerosis, hypertension and hyperlipidemia
6) Confidence 0.70 Published 1997 Journal Orv Hetil Section Abstract Doc Link 9340578 Disease Relevance 0.78 Pain Relevance 0.09
It would appear that the potential of the endothelium to release endothelium-dependent relaxant factor (EDRF) and the vasodilator response to EDRF are preserved, even in spastic segments.
Localization (release) of EDRF in endothelium associated with spasticity
7) Confidence 0.70 Published 1993 Journal Eur. Heart J. Section Abstract Doc Link 7507436 Disease Relevance 1.19 Pain Relevance 0.49
Acetylcholine stimulates muscarinic receptors of endothelial cells resulting in the release of endothelium-derived relaxing factor (EDRF), and possibly nitric oxide.
Localization (release) of EDRF in endothelial cells
8) Confidence 0.65 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0.05 Pain Relevance 0.41
Normal endothelium, in response to increases in shear stress, or to platelet products and other agonists, releases endothelium-derived relaxing factor(s) (EDRF) with resultant vasodilatation.
Localization (releases) of EDRF in platelet associated with stress, agonist and increased venous pressure under development
9) Confidence 0.62 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2038073 Disease Relevance 0.46 Pain Relevance 0.23
Furthermore, pre-incubation with gossypol, an inhibitor of the formation and release of endothelium-derived relaxing factors (EDRF), completely abolished the effects of SP without influencing the dilatory action of CGRP.
Localization (release) of EDRF in endothelium associated with calcitonin gene-related peptide and substance p
10) Confidence 0.53 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2476911 Disease Relevance 0.07 Pain Relevance 1.08
By correlating the ultrasound findings with the pharmacological findings, it might be considered that dilatation of the varicose vein segments with slow return to initial resting diameter represents a contraction dysfunction of the venous wall initiated most probably by the endothelium due to deficient EDCF or due to a release of EDRF in a healthy vascular smooth muscle fibres in the venous wall of the varicose vein group.
Localization (release) of EDRF in smooth muscle associated with increased venous pressure under development
11) Confidence 0.33 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570569 Disease Relevance 0.73 Pain Relevance 0.03

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