INT17021

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.45
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AHSP) protein folding (AHSP) cytoplasm (AHSP)
Anatomy Link Frequency
plaques 1
vessels 1
smooth muscle cell 1
AHSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 6 98.80 Very High Very High Very High
agonist 1 89.00 High High
Serotonin 3 85.44 High High
5HT 1 84.56 Quite High
cva 4 72.68 Quite High
antagonist 1 60.96 Quite High
ischemia 1 51.80 Quite High
headache 1 40.40 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 2 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 10 99.58 Very High Very High Very High
Cv General 3 Under Development 10 98.80 Very High Very High Very High
Atherosclerotic Plaque 1 98.80 Very High Very High Very High
Injury 1 95.84 Very High Very High Very High
Aids-related Complex 1 91.20 High High
Hyperlipidemia 1 90.80 High High
Pathologic Constriction 3 89.84 High High
Atherosclerosis 5 89.80 High High
Hypertension 5 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impairment of EDRF may also account for smooth muscle cell proliferation and migration.
Negative_regulation (Impairment) of EDRF in smooth muscle cell
1) Confidence 0.43 Published 1997 Journal Orv Hetil Section Abstract Doc Link 9340578 Disease Relevance 0.80 Pain Relevance 0.10
The tendency for coronary arteries to constrict in presence of atherosclerosis is explained by the lack of EDRF, especially in the region of atherosclerotic plaques where the endothelium is often absent or has lost its endocrine function.
Negative_regulation (lack) of EDRF in plaques associated with atherosclerotic plaque and increased venous pressure under development
2) Confidence 0.43 Published 1989 Journal Z Kardiol Section Abstract Doc Link 2511690 Disease Relevance 0.66 Pain Relevance 0.13
In porcine coronary vessels the amount of EDRF released can be increased by a diet of codliver oil and decreased by a high cholesterol diet.
Negative_regulation (decreased) of EDRF in vessels
3) Confidence 0.43 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2038073 Disease Relevance 0.55 Pain Relevance 0.25
Is there a clinically significant effect of anesthetics on basal activity of EDRF, or only in response to exogenous stimulation?
Negative_regulation (effect) of EDRF
4) Confidence 0.43 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.81 Pain Relevance 0.10
Abnormal vasomotor responses are a feature of both human and experimental atheromatous coronary arteries; such an abnormality is likely to reflect endothelial dysfunction with loss or neutralization of endothelial-derived relaxant factor (EDRF).
Negative_regulation (loss) of EDRF
5) Confidence 0.41 Published 1989 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 2487798 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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