INT170228

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PLTP) transport (PLTP) extracellular region (PLTP)
lipid metabolic process (PLTP)
PLTP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 48.56 Quite Low
Angina 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 255 100.00 Very High Very High Very High
Targeted Disruption 53 95.92 Very High Very High Very High
Diabetes Mellitus 20 90.88 High High
Obesity 12 89.52 High High
Aging 4 89.00 High High
Coronary Artery Disease 60 85.56 High High
Nicotine Addiction 9 82.12 Quite High
Hypertension 16 81.76 Quite High
Atherosclerosis 20 53.40 Quite High
Adult Respiratory Distress Syndrome 52 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution of PLTP activity and Lp(a) levels was positively skewed and so were naturally log transformed prior to analyses.
Negative_regulation (distribution) of PLTP
1) Confidence 0.43 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 0.34 Pain Relevance 0
PLTP deficiency has not been found in humans while numerous PLTP polymorphisms were identified.
Negative_regulation (deficiency) of PLTP
2) Confidence 0.43 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 0.69 Pain Relevance 0
However, no statistical significant difference of PLTP activity was found between the 'CC' and 'GC' groups (P = 0.26).
Neg (no) Negative_regulation (difference) of PLTP
3) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 0.63 Pain Relevance 0
PLTP activity contributes to the generation of large HDL as well as small HDL particles [22,23] and may promote catabolism of these particles, thus decreasing HDL levels.
Negative_regulation (decreasing) of PLTP associated with disorder of lipid metabolism
4) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 1.94 Pain Relevance 0
Part of the species differences observed in mice and in rats may result from their high levels of circulating lipases [25,26], lack of CETP [27] and high levels of PLTP [10].
Negative_regulation (lack) of PLTP
5) Confidence 0.14 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 1.07 Pain Relevance 0
At T0 and thus ~12 h after intubation, severe and highly significant alterations to the surfactant system were encountered, with a ten-fold reduced phospholipid-to-protein ratio (Table 2), a large reduction in the relative amount of large surfactant aggregates (LA, Figure 1), a pronounced disturbance to the phospholipid and PC molecular species profile (Table 2) and a significant loss of all surfactant proteins (Table 2).
Negative_regulation (reduction) of phospholipid-to-protein
6) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0

General Comments

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