INT170238

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.74
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
blood 2
leukocytes 2
striatum 2
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 156 99.08 Very High Very High Very High
positron emission tomography 92 98.32 Very High Very High Very High
diabetic neuropathy 33 93.56 High High
Potency 1 84.08 Quite High
imagery 46 79.84 Quite High
monoamine 12 75.60 Quite High
anesthesia 2 62.48 Quite High
Inflammation 24 11.24 Low Low
Substantia nigra 12 5.00 Very Low Very Low Very Low
Osteoarthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 8 99.16 Very High Very High Very High
Aging 36 98.48 Very High Very High Very High
Diabetic Neuropathy 34 93.56 High High
Cytomegalovirus Infection 6 82.48 Quite High
Disease 144 80.00 Quite High
Parkinsonian Disorders 78 79.48 Quite High
Stress 15 79.28 Quite High
Parkinson's Disease 10 67.60 Quite High
Targeted Disruption 1 67.36 Quite High
Hypokinesia 13 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no significant reduction in CD235a expression was seen in cells expressing HOXA9 and HOXA9?
Neg (no) Negative_regulation (reduction) of Gene_expression (expression) of CD235a
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
On the other hand, cells expressing NUP98-HOXA9/N51S did not show morphologic evidence of erythroid immaturity in Giemsa-stained preparations (Fig. 8 and Table 1); yet a clear block in erythroid differentiation was observed by flow cytometry as evidenced by decreased expression of CD235a (Fig. 9A).
Negative_regulation (decreased) of Gene_expression (expression) of CD235a
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.08 Pain Relevance 0
Mitochondrial Mn-SOD activity is preserved in recreationally active, but not sedentary, older adults
Negative_regulation (preserved) of Gene_expression (activity) of Mn-SOD
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.44 Pain Relevance 0.04
However this mutation is more likely to be involve in hereditary aging-related neurodegenerative disease, as shown by the finding that leukocytes lose the ability to induce Mn-SOD expression in response to increases in reactive oxygen species levels in tissue, in subjects over the age of 55 years [14].
Negative_regulation (lose) of Gene_expression (expression) of Mn-SOD in leukocytes associated with aging and neurodegenerative disease
4) Confidence 0.17 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.73 Pain Relevance 0.10
However, a firm conclusion that chronic Mn results in the loss of DAT and presumably dopamine neuron terminals in the striatum cannot be made because [11C]-nomifensine is not a selective DAT ligand and because Mn can directly inhibit ligand binding to DAT.
Negative_regulation (loss) of Gene_expression (results) of Mn in striatum associated with dopamine
5) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.59
g/L, but the blood Mn concentrations in these young addicts have been measured at levels as high as 2,000–3,000 ?
Negative_regulation (blood) of Gene_expression (concentrations) of Mn in blood
6) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.49 Pain Relevance 0.14

General Comments

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