INT170239

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Context Info
Confidence 0.07
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.15
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VARS) mitochondrion (VARS) intracellular (VARS)
ligase activity (VARS) cytoplasm (VARS)
Anatomy Link Frequency
EB-1 1
GRANTA-519 1
HC-1 1
IM-9 1
VARS (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 87 100.00 Very High Very High Very High
Nortriptyline 6 80.80 Quite High
fluoxetine 6 80.12 Quite High
diabetic neuropathy 33 69.84 Quite High
depression 27 67.68 Quite High
addiction 39 13.40 Low Low
Dopamine 39 5.00 Very Low Very Low Very Low
alcohol 13 5.00 Very Low Very Low Very Low
dopamine receptor 9 5.00 Very Low Very Low Very Low
IPN 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Personality Disorder 3 91.12 High High
Stress 10 89.60 High High
Severe Combined Immunodeficiency 21 88.12 High High
Diabetes Mellitus 20 82.00 Quite High
Aging 3 79.60 Quite High
Neurological Disease 2 78.72 Quite High
Epstein-barr Virus 548 78.64 Quite High
Diabetic Neuropathy 34 69.84 Quite High
Depression 36 67.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 172 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The COMT Met and Val allele frequencies were .46 and .54, respectively.
Gene_expression (frequencies) of Val associated with catechol-o-methyltransferase
1) Confidence 0.07 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.13
Consistent with Reuter et al. [1] the gene loci were considered in two ways: (1) presence of an allele (DRD2 TaqI A1 or COMT Val) and (2) genotype.
Gene_expression (presence) of Val associated with catechol-o-methyltransferase
2) Confidence 0.06 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0.11 Pain Relevance 0.08
The G (Val) allele was detected using the primers 5'-TCACCCAGCGGATGGTGGATTTCGCTGGGG-3' and 5'-AACGTGGTGTGAACACCTGGTGGGGAG-3', yielding a 143 bp product.
Gene_expression (detected) of Val
3) Confidence 0.06 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0.46 Pain Relevance 0.20
The Val variant of the Mn-SOD may be present in a lower concentration in mitochondria.
Gene_expression (present) of Val
4) Confidence 0.01 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.52 Pain Relevance 0.06
Six additional cell lines which showed no expression in the absence of TPA/Na-butyrate produced the ZEBRA protein in various amounts after induction of the lytic phase with TPA (EB-1, GRANTA-519, HC-1, IM-9, JIYOYE, and VAL).
Gene_expression (produced) of VAL in GRANTA-519
5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.27 Pain Relevance 0
Among Met/Met and Val/Met carriers, an increase in executive deficit scores were associated with an increased frequency of insertive (Met/Met: ?
Gene_expression (/) of Val
6) Confidence 0.01 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
= 0.18; Val/Met: ?
Gene_expression (0.18) of Val
7) Confidence 0.01 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
= 0.13; Val/Met: ?
Gene_expression (0.13) of Val
8) Confidence 0.01 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
The residues Trp, Tyr and Val are highly favored on the designed peptides.
Gene_expression (favored) of Val
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
Six additional cell lines which showed no expression in the absence of TPA/Na-butyrate produced the ZEBRA protein in various amounts after induction of the lytic phase with TPA (EB-1, GRANTA-519, HC-1, IM-9, JIYOYE, and VAL).
Gene_expression (produced) of VAL in IM-9
10) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.27 Pain Relevance 0
Six additional cell lines which showed no expression in the absence of TPA/Na-butyrate produced the ZEBRA protein in various amounts after induction of the lytic phase with TPA (EB-1, GRANTA-519, HC-1, IM-9, JIYOYE, and VAL).
Gene_expression (produced) of VAL in EB-1
11) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.27 Pain Relevance 0
Six additional cell lines which showed no expression in the absence of TPA/Na-butyrate produced the ZEBRA protein in various amounts after induction of the lytic phase with TPA (EB-1, GRANTA-519, HC-1, IM-9, JIYOYE, and VAL).
Gene_expression (produced) of VAL in HC-1
12) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.27 Pain Relevance 0

General Comments

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