INT17024

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 69
Total Number 69
Disease Relevance 36.38
Pain Relevance 8.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
fibroblasts 5
osteoblasts 5
chondrocyte 4
cartilage 4
ECM 2
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 17 99.76 Very High Very High Very High
Pain 92 99.64 Very High Very High Very High
rheumatoid arthritis 80 99.60 Very High Very High Very High
cytokine 114 99.44 Very High Very High Very High
chemokine 10 98.88 Very High Very High Very High
Osteoarthritis 532 98.24 Very High Very High Very High
palliative 6 97.40 Very High Very High Very High
metalloproteinase 152 95.76 Very High Very High Very High
Inflammation 232 95.36 Very High Very High Very High
fibrosis 255 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 81 99.60 Very High Very High Very High
Hypoxia 22 99.60 Very High Very High Very High
Cicatrix 16 99.50 Very High Very High Very High
Hypercalcemia 100 99.48 Very High Very High Very High
Obesity 535 99.38 Very High Very High Very High
INFLAMMATION 240 99.36 Very High Very High Very High
Osteogenesis Imperfecta 127 99.08 Very High Very High Very High
Metabolic Bone Disease 6 98.92 Very High Very High Very High
Injury 272 98.84 Very High Very High Very High
Reprotox - General 1 17 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell proliferation and mRNA expressions of type I collagen and decorin were then measured.
Gene_expression (expressions) of type I collagen
1) Confidence 0.77 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.16 Pain Relevance 0.12
Therefore, suitable dosages of LLLI may result in more effective tissue healing by promoting type I collagen and decorin synthesis.
Gene_expression (synthesis) of type I collagen
2) Confidence 0.77 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.11 Pain Relevance 0.08
The mRNA expressions of decorin and type I collagen in fibroblasts with LLLI were significantly higher (p < 0.05).
Gene_expression (expressions) of type I collagen in fibroblasts
3) Confidence 0.77 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.12 Pain Relevance 0.09
Genetic testing can be done by DNA testing (molecular study), on peripheral blood or on saliva specimens, or looking at the protein expression of type I procollagen (biochemical studies), on cultured fibroblasts from a skin biopsy.
Gene_expression (expression) of type I procollagen in fibroblasts
4) Confidence 0.75 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.87 Pain Relevance 0
Except for the patient with mild osteogenesis imperfecta, cultured dermal fibroblasts synthesized and exported normal Type I collagen.
Gene_expression (exported) of Type I collagen in fibroblasts associated with osteogenesis imperfecta
5) Confidence 0.66 Published 1995 Journal QJM Section Abstract Doc Link 8593546 Disease Relevance 1.09 Pain Relevance 0.19
Type I collagen, laminin, and tenascin were found in the framework of the sheath-like structure.
Gene_expression (found) of Type I collagen
6) Confidence 0.63 Published 1996 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 8665306 Disease Relevance 0.25 Pain Relevance 0.25
New methods for the measurement of bone resorption, such as the degradation product of type I collagen (ICTP), may improve the possibility of monitoring the effect of clodronate.
Gene_expression (product) of type I collagen associated with hypercalcemia
7) Confidence 0.59 Published 1995 Journal Acta Oncol Section Abstract Doc Link 7546830 Disease Relevance 0.87 Pain Relevance 0.09
These results suggest that HA at 100 microg/ml not only influences chondrocytes to differentiate and produce more Collagen II and aggrecan, but also increases proliferation.
Gene_expression (produce) of Collagen II in chondrocytes
8) Confidence 0.53 Published 2001 Journal Ann. Anat. Section Abstract Doc Link 11206979 Disease Relevance 0.08 Pain Relevance 0.04
Type I collagen is present in many tissues, including blood vessels.
Gene_expression (present) of Type I collagen in blood vessels
9) Confidence 0.49 Published 2006 Journal Am J Forensic Med Pathol Section Abstract Doc Link 16738428 Disease Relevance 1.82 Pain Relevance 0.09
Hypoxia induced migration, type I collagen expression, and vascular endothelial growth factor (VEGF) production in PSCs.
Gene_expression (expression) of type I collagen in PSCs associated with hypoxia
10) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.60 Pain Relevance 0.19
Type I procollagen (CI), expressed in many different tissues, was also included as control.
Gene_expression (expressed) of Type I procollagen
11) Confidence 0.39 Published 1994 Journal Eur. J. Immunol. Section Abstract Doc Link 8026527 Disease Relevance 0.79 Pain Relevance 0.59
We determined the reference interval for the carboxyterminal propeptide of type I procollagen (PICP), an indicator of the synthesis of type I collagen, in cerebrospinal fluid (CSF) by studying 32 infants and children, ages less than or equal to 15 years.
Gene_expression (synthesis) of type I collagen in CSF
12) Confidence 0.38 Published 1991 Journal Clin. Chem. Section Abstract Doc Link 1868595 Disease Relevance 0.14 Pain Relevance 0.07
Our data demonstrates that Type I Collagen, Decorin, Cathepsin K, and MMP2 gene expression are relatively insensitive to unloaded culture conditions.
Gene_expression (expression) of Type I Collagen
13) Confidence 0.38 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18404723 Disease Relevance 0.39 Pain Relevance 0.11
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Gene_expression (expression) of type I collagen
14) Confidence 0.33 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
Reductions in serum C-terminal telopeptide of type I collagen (?
Gene_expression (Reductions) of type I collagen
15) Confidence 0.30 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682377 Disease Relevance 0 Pain Relevance 0.06
For each patient, pretreatment and posttreatment serum levels of osteocalcin (OC), bone alkaline phosphatase (BALP), aminoterminal (PINP) and carboxyterminal (PICP) propeptides of type I collagen, amino-terminal (NTx) and carboxyterminal (CTx) telopeptides of type I collagen and their combinations were compared with the level and duration of pain response to radionuclide treatment.
Gene_expression (levels) of type I collagen
16) Confidence 0.29 Published 2010 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 19662405 Disease Relevance 0.16 Pain Relevance 0
For each patient, pretreatment and posttreatment serum levels of osteocalcin (OC), bone alkaline phosphatase (BALP), aminoterminal (PINP) and carboxyterminal (PICP) propeptides of type I collagen, amino-terminal (NTx) and carboxyterminal (CTx) telopeptides of type I collagen and their combinations were compared with the level and duration of pain response to radionuclide treatment.
Gene_expression (levels) of type I collagen
17) Confidence 0.29 Published 2010 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 19662405 Disease Relevance 0.16 Pain Relevance 0
Type I collagen is synthesized by osteoblasts as a precursor protein termed procollagen I.
Gene_expression (synthesized) of Type I collagen in osteoblasts
18) Confidence 0.29 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.24 Pain Relevance 0.12
At 12 months, the levels of serum CTx, bone-specific ALP, and N-terminal propeptide of Type I collagen were 59%, 30%, and 58% lower, respectively, in the zoledronic acid group than in the placebo group (P < 0.001 for all groups).25
Gene_expression (levels) of Type I collagen
19) Confidence 0.23 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 0.39 Pain Relevance 0
Because the proteinase resistance of type I collagen can be compromised at temperatures within 10°C of that at which the helix reversibly unfolds [4], reconstituted fibrillar collagen may provide a less resistant substrate to proteolytic activity.
Gene_expression (resistance) of type I collagen
20) Confidence 0.21 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.65 Pain Relevance 0

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